The involvement of N-methyl-d-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle

Volker Neugebauer; Thomas Lücke; Blair Grubb; Hans Georg Schaible

doi:10.1016/0304-3940(94)90327-1

The involvement of N-methyl-d-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle

Volker Neugebauer
, Thomas Lücke
, Blair Grubb
, Hans Georg Schaible (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Unilateral adjuvant inflammation was induced at the rat ankle 2 or 20 days before an evaluation of the contribution of N-methyl-d-aspartate (NMDA) and non-NMDA receptors to the processing of nociceptive information by wide dynamic range neurons in the spinal cord. Microionophoretic application of either the NMDA receptor antagonists ketamine and DL-2-amino-5-phosphonovalerate (AP5) or the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the responses to innocuous and noxious mechanical stimulation of the inflamed ankle. The pattern of these effects was comparable to that in rats with acute inflammation suggesting that non-NMDA and NMDA receptors are similarly involved in acute, prolonged acute and chronic inflammation-evoked activity.

Original language	English
Pages (from-to)	237-240
Number of pages	4
Journal	Neuroscience Letters
Volume	170
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(94)90327-1
Publication status	Published - 11 Apr 1994

Keywords

AP5
Arthritis
CNQX
Joint nociception
Ketamine
NMDA receptor antagonist
Non-NMDA receptor antagonist
Rat spinal cord

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)90327-1

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title = "The involvement of N-methyl-d-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle",

abstract = "Unilateral adjuvant inflammation was induced at the rat ankle 2 or 20 days before an evaluation of the contribution of N-methyl-d-aspartate (NMDA) and non-NMDA receptors to the processing of nociceptive information by wide dynamic range neurons in the spinal cord. Microionophoretic application of either the NMDA receptor antagonists ketamine and DL-2-amino-5-phosphonovalerate (AP5) or the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the responses to innocuous and noxious mechanical stimulation of the inflamed ankle. The pattern of these effects was comparable to that in rats with acute inflammation suggesting that non-NMDA and NMDA receptors are similarly involved in acute, prolonged acute and chronic inflammation-evoked activity.",

keywords = "AP5, Arthritis, CNQX, Joint nociception, Ketamine, NMDA receptor antagonist, Non-NMDA receptor antagonist, Rat spinal cord",

author = "Volker Neugebauer and Thomas L{\"u}cke and Blair Grubb and Schaible, \{Hans Georg\}",

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AU - Neugebauer, Volker

AU - Lücke, Thomas

AU - Grubb, Blair

AU - Schaible, Hans Georg

PY - 1994/4/11

Y1 - 1994/4/11

N2 - Unilateral adjuvant inflammation was induced at the rat ankle 2 or 20 days before an evaluation of the contribution of N-methyl-d-aspartate (NMDA) and non-NMDA receptors to the processing of nociceptive information by wide dynamic range neurons in the spinal cord. Microionophoretic application of either the NMDA receptor antagonists ketamine and DL-2-amino-5-phosphonovalerate (AP5) or the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the responses to innocuous and noxious mechanical stimulation of the inflamed ankle. The pattern of these effects was comparable to that in rats with acute inflammation suggesting that non-NMDA and NMDA receptors are similarly involved in acute, prolonged acute and chronic inflammation-evoked activity.

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KW - AP5

KW - Arthritis

KW - CNQX

KW - Joint nociception

KW - Ketamine

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KW - Non-NMDA receptor antagonist

KW - Rat spinal cord

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ER -

The involvement of N-methyl-d-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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