The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Christopher Southan; Joanna L. Sharman; Helen E. Benson; Elena Faccenda; Adam J. Pawson; Stephen P. H. Alexander; O. Peter Buneman; Anthony P. Davenport; John C. McGrath; John A. Peters; Michael Spedding; William A. Catterall; Doriano Fabbro; Jamie A. Davies; NC-IUPHAR

doi:10.1093/nar/gkv1037

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Christopher Southan, Joanna L. Sharman, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Stephen P. H. Alexander, O. Peter Buneman, Anthony P. Davenport, John C. McGrath, John A. Peters, Michael Spedding, William A. Catterall, Doriano Fabbro, Jamie A. Davies (Lead / Corresponding author), NC-IUPHAR

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Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options.

Original language	English
Pages (from-to)	D1054-D1068
Number of pages	15
Journal	Nucleic Acids Research
Volume	44
Issue number	D1
Early online date	12 Oct 2015
DOIs	https://doi.org/10.1093/nar/gkv1037
Publication status	Published - 4 Jan 2016

Keywords

Biological ontologies
Databases, Pharmaceutical
Disease
Drug discovery
Genome, Human
Humans
Internet
Ligands
Patents as topic
Phosphotransferases
Proteins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/nar/gkv1037Licence: CC BY

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 4.3 MBLicence: CC BY

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Southan, C., Sharman, J. L., Benson, H. E., Faccenda, E., Pawson, A. J., Alexander, S. P. H., Buneman, O. P., Davenport, A. P., McGrath, J. C., Peters, J. A., Spedding, M., Catterall, W. A., Fabbro, D., Davies, J. A., & NC-IUPHAR (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Research, 44(D1), D1054-D1068. https://doi.org/10.1093/nar/gkv1037

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abstract = "The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options.",

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author = "Christopher Southan and Sharman, {Joanna L.} and Benson, {Helen E.} and Elena Faccenda and Pawson, {Adam J.} and Alexander, {Stephen P. H.} and Buneman, {O. Peter} and Davenport, {Anthony P.} and McGrath, {John C.} and Peters, {John A.} and Michael Spedding and Catterall, {William A.} and Doriano Fabbro and Davies, {Jamie A.} and NC-IUPHAR",

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Southan, C, Sharman, JL, Benson, HE, Faccenda, E, Pawson, AJ, Alexander, SPH, Buneman, OP, Davenport, AP, McGrath, JC, Peters, JA, Spedding, M, Catterall, WA, Fabbro, D, Davies, JA & NC-IUPHAR 2016, 'The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands', Nucleic Acids Research, vol. 44, no. D1, pp. D1054-D1068. https://doi.org/10.1093/nar/gkv1037

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AU - Southan, Christopher

AU - Sharman, Joanna L.

AU - Benson, Helen E.

AU - Faccenda, Elena

AU - Pawson, Adam J.

AU - Alexander, Stephen P. H.

AU - Buneman, O. Peter

AU - Davenport, Anthony P.

AU - McGrath, John C.

AU - Peters, John A.

AU - Spedding, Michael

AU - Catterall, William A.

AU - Fabbro, Doriano

AU - Davies, Jamie A.

AU - NC-IUPHAR

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KW - Biological ontologies

KW - Databases, Pharmaceutical

KW - Disease

KW - Drug discovery

KW - Genome, Human

KW - Humans

KW - Internet

KW - Ligands

KW - Patents as topic

KW - Phosphotransferases

KW - Proteins

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DO - 10.1093/nar/gkv1037

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SN - 0305-1048

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JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - D1

ER -

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Abstract

Keywords

UN SDGs

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