The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Christopher Southan, Joanna L. Sharman, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Stephen P. H. Alexander, O. Peter Buneman, Anthony P. Davenport, John C. McGrath, John A. Peters, Michael Spedding, William A. Catterall, Doriano Fabbro, Jamie A. Davies (Lead / Corresponding author), NC-IUPHAR

    Research output: Contribution to journalArticlepeer-review

    953 Citations (Scopus)
    265 Downloads (Pure)

    Abstract

    The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. Developed by the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS), this resource, and its earlier incarnation as IUPHAR-DB, is described in our 2014 publication. This update incorporates changes over the intervening seven database releases. The unique model of content capture is based on established and new target class subcommittees collaborating with in-house curators. Most information comes from journal articles, but we now also index kinase cross-screening panels. Targets are specified by UniProtKB IDs. Small molecules are defined by PubChem Compound Identifiers (CIDs); ligand capture also includes peptides and clinical antibodies. We have extended the capture of ligands and targets linked via published quantitative binding data (e.g. Ki, IC50 or Kd). The resulting pharmacological relationship network now defines a data-supported druggable genome encompassing 7% of human proteins. The database also provides an expanded substrate for the biennially published compendium, the Concise Guide to PHARMACOLOGY. This article covers content increase, entity analysis, revised curation strategies, new website features and expanded download options.

    Original languageEnglish
    Pages (from-to)D1054-D1068
    Number of pages15
    JournalNucleic Acids Research
    Volume44
    Issue numberD1
    Early online date12 Oct 2015
    DOIs
    Publication statusPublished - 4 Jan 2016

    Keywords

    • Biological ontologies
    • Databases, Pharmaceutical
    • Disease
    • Drug discovery
    • Genome, Human
    • Humans
    • Internet
    • Ligands
    • Patents as topic
    • Phosphotransferases
    • Proteins

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