The kinomes of apicomplexan parasites

Diego Miranda-Saavedra; Toni Gabaldón; Geoffrey J. Barton; Gordon Langsley; Christian Doerig

doi:10.1016/j.micinf.2012.04.007

The kinomes of apicomplexan parasites

Diego Miranda-Saavedra, Toni Gabaldón, Geoffrey J. Barton, Gordon Langsley, Christian Doerig

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61 Citations (Scopus)

Abstract

Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.

Original language	English
Pages (from-to)	796-810
Number of pages	15
Journal	Microbes and Infection
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/j.micinf.2012.04.007
Publication status	Published - 2012

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The kinomes of apicomplexan parasites

Abstract

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