The kinomes of apicomplexan parasites

Diego Miranda-Saavedra, Toni Gabaldón, Geoffrey J. Barton, Gordon Langsley, Christian Doerig

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.
    Original languageEnglish
    Pages (from-to)796-810
    Number of pages15
    JournalMicrobes and Infection
    Volume14
    Issue number10
    DOIs
    Publication statusPublished - 2012

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    Protein Kinases
    Molecular Biology
    Parasites
    Phosphorylation
    Databases
    Pharmaceutical Preparations
    Proteins

    Cite this

    Miranda-Saavedra, D., Gabaldón, T., Barton, G. J., Langsley, G., & Doerig, C. (2012). The kinomes of apicomplexan parasites. Microbes and Infection, 14(10), 796-810. https://doi.org/10.1016/j.micinf.2012.04.007
    Miranda-Saavedra, Diego ; Gabaldón, Toni ; Barton, Geoffrey J. ; Langsley, Gordon ; Doerig, Christian. / The kinomes of apicomplexan parasites. In: Microbes and Infection. 2012 ; Vol. 14, No. 10. pp. 796-810.
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    Miranda-Saavedra, D, Gabaldón, T, Barton, GJ, Langsley, G & Doerig, C 2012, 'The kinomes of apicomplexan parasites', Microbes and Infection, vol. 14, no. 10, pp. 796-810. https://doi.org/10.1016/j.micinf.2012.04.007

    The kinomes of apicomplexan parasites. / Miranda-Saavedra, Diego; Gabaldón, Toni; Barton, Geoffrey J.; Langsley, Gordon; Doerig, Christian.

    In: Microbes and Infection, Vol. 14, No. 10, 2012, p. 796-810.

    Research output: Contribution to journalArticle

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    Miranda-Saavedra D, Gabaldón T, Barton GJ, Langsley G, Doerig C. The kinomes of apicomplexan parasites. Microbes and Infection. 2012;14(10):796-810. https://doi.org/10.1016/j.micinf.2012.04.007