The kinomes of apicomplexan parasites

Diego Miranda-Saavedra, Toni Gabaldón, Geoffrey J. Barton, Gordon Langsley, Christian Doerig

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)

    Abstract

    Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.
    Original languageEnglish
    Pages (from-to)796-810
    Number of pages15
    JournalMicrobes and Infection
    Volume14
    Issue number10
    DOIs
    Publication statusPublished - 2012

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