The L7Ae proteins mediate a widespread and highly functional protein-RNA interaction

David M.J. Lilley (Lead / Corresponding author)

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Abstract

The k-turn is a ubiquitous structural motif in RNA forming a very tight kink in the axis of helical RNA that plays an important role in many aspects of RNA function. L7Ae is a member of a superfamily of proteins that bind k-turns in RNA, stabilizing the tightly kinked conformation. They are extremely widespread and are important in the assembly of RNA-protein complexes central to translation, splicing and site-specific RNA modification. The interaction is exploited in order to regulate the synthesis of L7Ae proteins and is itself subject to regulation in box C/D snoRNP assembly by N6 methylation of a key adenine in the k-turn. Lastly, we can exploit the L7Ae-k-turn interaction in the construction of nanoscale assemblies.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalBiochemist
Volume41
Issue number2
DOIs
Publication statusPublished - Apr 2019

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