The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia – time to unravel the challenges

M. Joseph John; Philip Kuriakose; Mark Smith; Eve Roman; Sudhir Tauro

doi:10.1038/s41408-021-00533-0

The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia – time to unravel the challenges

M. Joseph John
, Philip Kuriakose
, Mark Smith
, Eve Roman
, Sudhir Tauro (Lead / Corresponding author)

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

94 Downloads (Pure)

Abstract

Biological and non-biological variables unrelated to acute myeloid leukemia (AML) preclude standard therapy in many settings, with ‘real world’ patients under-represented in clinical trials and prognostic models. Here, using a case-based format, we illustrate the impact that socioeconomic and anthropogeographical constraints can have on optimally managing AML in 4 different healthcare systems. The granular details provided, emphasize the need for the development and targeting of socioeconomic interventions that are commensurate with the changing landscape of AML therapeutics, in order to avoid worsening the disparity in outcomes between patients with biologically similar disease.

Original language	English
Article number	141
Number of pages	8
Journal	Blood Cancer Journal
Volume	11
Issue number	8
DOIs	https://doi.org/10.1038/s41408-021-00533-0
Publication status	Published - 6 Aug 2021

Keywords

Acute myeloid leukaemia
Therapeutics

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10.1038/s41408-021-00533-0Licence: CC BY

Final Published VersionFinal published version, 501 KBLicence: CC BY

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AU - Tauro, Sudhir

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AB - Biological and non-biological variables unrelated to acute myeloid leukemia (AML) preclude standard therapy in many settings, with ‘real world’ patients under-represented in clinical trials and prognostic models. Here, using a case-based format, we illustrate the impact that socioeconomic and anthropogeographical constraints can have on optimally managing AML in 4 different healthcare systems. The granular details provided, emphasize the need for the development and targeting of socioeconomic interventions that are commensurate with the changing landscape of AML therapeutics, in order to avoid worsening the disparity in outcomes between patients with biologically similar disease.

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KW - Therapeutics

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The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia – time to unravel the challenges

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Keywords

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