The making of the mitotic chromosome: Modern insights into classical questions

Jason R. Swedlow, Tatsuya Hirano (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

228 Citations (Scopus)

Abstract

The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.

Original languageEnglish
Pages (from-to)557-569
Number of pages13
JournalMolecular Cell
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Mar 2003

Fingerprint

Dive into the research topics of 'The making of the mitotic chromosome: Modern insights into classical questions'. Together they form a unique fingerprint.

Cite this