@article{85feb4f425314bf0b87b5bce333d05a8,
title = "The making of the mitotic chromosome: Modern insights into classical questions",
abstract = "The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.",
author = "Swedlow, {Jason R.} and Tatsuya Hirano",
note = "Funding Information: The authors are grateful to Bill Earnshaw, Margarete Heck, Uli Laemmli, Susan Gasser, Terence Strick, David Bazett-Jones, Harold Erickson, Nick Cozzarelli, Mitsuhiro Yanagida, and many other colleagues in the field for stimulating discussions. Special thanks go to Kim Nasmyth who inspired T.H. to further refine the chiral looping model. The work from the authors' laboratories was supported by grants from the Wellcome Trust and Cancer Research UK (to J.R.S.) and the National Institutes of Health (to T.H.). J.R.S. is a Wellcome Trust Senior Research Fellow.",
year = "2003",
month = mar,
day = "1",
doi = "10.1016/S1097-2765(03)00103-5",
language = "English",
volume = "11",
pages = "557--569",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Elsevier",
number = "3",
}