The making of the mitotic chromosome: Modern insights into classical questions

Jason R. Swedlow, Tatsuya Hirano (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    231 Citations (Scopus)

    Abstract

    The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.

    Original languageEnglish
    Pages (from-to)557-569
    Number of pages13
    JournalMolecular Cell
    Volume11
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2003

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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