The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome

Emma J. Crosbie; Neil A. J. Ryan; Mark J. Arends; Tjalling Bosse; John Burn; Joanna M. Cornes; Robin Crawford; Diana Eccles; Ian M. Frayling; Sadaf Ghaem-Maghami; Heather Hampel; Noah D. Kauff; Henry C. Kitchener; Sarah J. Kitson; Ranjit Manchanda; Raymond F. T. McMahon; Kevin J. Monahan; Usha Menon; Pål Møller; Gabriela Möslein; Adam Rosenthal; Peter Sasieni; Mourad W. Seif; Naveena Singh; Pauline Skarrott; Tristan M. Snowsill; Robert Steele; Marc Tischkowitz; D. Gareth Evans

doi:10.1038/s41436-019-0489-y

The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome

, Emma J. Crosbie (Lead / Corresponding author), Neil A. J. Ryan, Mark J. Arends, Tjalling Bosse, John Burn, Joanna M. Cornes, Robin Crawford, Diana Eccles, Ian M. Frayling, Sadaf Ghaem-Maghami, Heather Hampel, Noah D. Kauff, Henry C. Kitchener, Sarah J. Kitson, Ranjit Manchanda, Raymond F. T. McMahon, Kevin J. Monahan, Usha Menon, Pål MøllerGabriela Möslein, Adam Rosenthal, Peter Sasieni, Mourad W. Seif, Naveena Singh, Pauline Skarrott, Tristan M. Snowsill, Robert Steele, Marc Tischkowitz, D. Gareth Evans

Population Health and Genomics

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Abstract

Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 in order to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.

Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.

Results: Guidance was developed in four key areas: 1) whether women with gynecological cancer should be screened for Lynch syndrome and 2) how this should be done; 3) whether there was a role for gynecological surveillance in women with proven Lynch syndrome; and 4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.

Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

Original language	English
Pages (from-to)	2390-2400
Number of pages	11
Journal	Genetics in Medicine
Volume	21
Issue number	10
Early online date	28 Mar 2019
DOIs	https://doi.org/10.1038/s41436-019-0489-y
Publication status	Published - Oct 2019

Keywords

endometrial cancer
guidance
Lynch syndrome
screening
surveillance

ASJC Scopus subject areas

Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41436-019-0489-y

Final Published VersionFinal published version, 464 KBLicence: CC BY

Cite this

, Crosbie, E. J., Ryan, N. A. J., Arends, M. J., Bosse, T., Burn, J., Cornes, J. M., Crawford, R., Eccles, D., Frayling, I. M., Ghaem-Maghami, S., Hampel, H., Kauff, N. D., Kitchener, H. C., Kitson, S. J., Manchanda, R., McMahon, R. F. T., Monahan, K. J., Menon, U., ... Evans, D. G. (2019). The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome. Genetics in Medicine, 21(10), 2390-2400. https://doi.org/10.1038/s41436-019-0489-y

@article{8c00908209344cec8a139e24961a18e9,

title = "The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome",

abstract = "Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 in order to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.Results: Guidance was developed in four key areas: 1) whether women with gynecological cancer should be screened for Lynch syndrome and 2) how this should be done; 3) whether there was a role for gynecological surveillance in women with proven Lynch syndrome; and 4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.",

keywords = "endometrial cancer, guidance, Lynch syndrome, screening, surveillance",

author = "Crosbie, {Emma J.} and Ryan, {Neil A. J.} and Arends, {Mark J.} and Tjalling Bosse and John Burn and Cornes, {Joanna M.} and Robin Crawford and Diana Eccles and Frayling, {Ian M.} and Sadaf Ghaem-Maghami and Heather Hampel and Kauff, {Noah D.} and Kitchener, {Henry C.} and Kitson, {Sarah J.} and Ranjit Manchanda and McMahon, {Raymond F. T.} and Monahan, {Kevin J.} and Usha Menon and P{\aa}l M{\o}ller and Gabriela M{\"o}slein and Adam Rosenthal and Peter Sasieni and Seif, {Mourad W.} and Naveena Singh and Pauline Skarrott and Snowsill, {Tristan M.} and Robert Steele and Marc Tischkowitz and Evans, {D. Gareth}",

note = "This work was funded by the National Institute for Health Research (NIHR) and Medical Research Council (MRC), United Kingdom.",

year = "2019",

month = oct,

doi = "10.1038/s41436-019-0489-y",

language = "English",

volume = "21",

pages = "2390--2400",

journal = "Genetics in Medicine",

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Crosbie, EJ, Ryan, NAJ, Arends, MJ, Bosse, T, Burn, J, Cornes, JM, Crawford, R, Eccles, D, Frayling, IM, Ghaem-Maghami, S, Hampel, H, Kauff, ND, Kitchener, HC, Kitson, SJ, Manchanda, R, McMahon, RFT, Monahan, KJ, Menon, U, Møller, P, Möslein, G, Rosenthal, A, Sasieni, P, Seif, MW, Singh, N, Skarrott, P, Snowsill, TM, Steele, R & Tischkowitz, M & Evans, DG 2019, 'The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome', Genetics in Medicine, vol. 21, no. 10, pp. 2390-2400. https://doi.org/10.1038/s41436-019-0489-y

TY - JOUR

T1 - The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome

AU - Crosbie, Emma J.

AU - Ryan, Neil A. J.

AU - Arends, Mark J.

AU - Bosse, Tjalling

AU - Burn, John

AU - Cornes, Joanna M.

AU - Crawford, Robin

AU - Eccles, Diana

AU - Frayling, Ian M.

AU - Ghaem-Maghami, Sadaf

AU - Hampel, Heather

AU - Kauff, Noah D.

AU - Kitchener, Henry C.

AU - Kitson, Sarah J.

AU - Manchanda, Ranjit

AU - McMahon, Raymond F. T.

AU - Monahan, Kevin J.

AU - Menon, Usha

AU - Møller, Pål

AU - Möslein, Gabriela

AU - Rosenthal, Adam

AU - Sasieni, Peter

AU - Seif, Mourad W.

AU - Singh, Naveena

AU - Skarrott, Pauline

AU - Snowsill, Tristan M.

AU - Steele, Robert

AU - Tischkowitz, Marc

AU - Evans, D. Gareth

N1 - This work was funded by the National Institute for Health Research (NIHR) and Medical Research Council (MRC), United Kingdom.

PY - 2019/10

Y1 - 2019/10

N2 - Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 in order to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.Results: Guidance was developed in four key areas: 1) whether women with gynecological cancer should be screened for Lynch syndrome and 2) how this should be done; 3) whether there was a role for gynecological surveillance in women with proven Lynch syndrome; and 4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

AB - Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 in order to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.Results: Guidance was developed in four key areas: 1) whether women with gynecological cancer should be screened for Lynch syndrome and 2) how this should be done; 3) whether there was a role for gynecological surveillance in women with proven Lynch syndrome; and 4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

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KW - guidance

KW - Lynch syndrome

KW - screening

KW - surveillance

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DO - 10.1038/s41436-019-0489-y

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ER -

The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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