The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome

, Emma J. Crosbie (Lead / Corresponding author), Neil A. J. Ryan, Mark J. Arends, Tjalling Bosse, John Burn, Joanna M. Cornes, Robin Crawford, Diana Eccles, Ian M. Frayling, Sadaf Ghaem-Maghami, Heather Hampel, Noah D. Kauff, Henry C. Kitchener, Sarah J. Kitson, Ranjit Manchanda, Raymond F. T. McMahon, Kevin J. Monahan, Usha Menon, Pål MøllerGabriela Möslein, Adam Rosenthal, Peter Sasieni, Mourad W. Seif, Naveena Singh, Pauline Skarrott, Tristan M. Snowsill, Robert Steele, Marc Tischkowitz, D. Gareth Evans

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Abstract

Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 in order to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.

Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.

Results: Guidance was developed in four key areas: 1) whether women with gynecological cancer should be screened for Lynch syndrome and 2) how this should be done; 3) whether there was a role for gynecological surveillance in women with proven Lynch syndrome; and 4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.

Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.
Original languageEnglish
Pages (from-to)2390-2400
Number of pages11
JournalGenetics in Medicine
Volume21
Issue number10
Early online date28 Mar 2019
DOIs
Publication statusPublished - Oct 2019

Keywords

  • endometrial cancer
  • guidance
  • Lynch syndrome
  • screening
  • surveillance

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    , Crosbie, E. J., Ryan, N. A. J., Arends, M. J., Bosse, T., Burn, J., Cornes, J. M., Crawford, R., Eccles, D., Frayling, I. M., Ghaem-Maghami, S., Hampel, H., Kauff, N. D., Kitchener, H. C., Kitson, S. J., Manchanda, R., McMahon, R. F. T., Monahan, K. J., Menon, U., ... Evans, D. G. (2019). The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome. Genetics in Medicine, 21(10), 2390-2400. https://doi.org/10.1038/s41436-019-0489-y