Keyphrases
Activation Mechanism
100%
Interleukin-1 Receptor
100%
IRAK4
100%
IL-1 Receptor-associated Kinase 1 (IRAK1)
100%
Toll-like Receptor Agonists
100%
Interleukin-1β
40%
Human Cells
20%
Pharmacological Inhibitors
20%
Catalytic Activity
20%
Pellino-1
20%
Pam3CSK4
20%
Dimerization
10%
Constitutively Active
10%
Protein Kinase
10%
Dephosphorylation
10%
HEK293 Cells
10%
Cell-free Extract
10%
Protein Kinase Activity
10%
Autophosphorylation
10%
Allosteric Mechanism
10%
Primary Macrophages
10%
THP-1 Cells
10%
Active Protein
10%
Myeloid Differentiation Factor 88 (MyD88)
10%
Covalent Modification
10%
Intrinsic Activity
10%
Deubiquitylation
10%
Pharmacology, Toxicology and Pharmaceutical Science
Receptor Agonist
100%
Toll Like Receptor
100%
Interleukin 1 Receptor Associated Kinase 1
100%
Interleukin 1 Receptor
100%
Interleukin 1
66%
Protein Kinases
33%
Cell Extract
16%
Myeloid Differentiation Factor 88
16%
Intrinsic Activity
16%
Immunology and Microbiology
Interleukin 1
100%
Agonist
100%
Interleukin-1 Receptor-Associated Kinase
100%
Human Cell
33%
Macrophage
16%
Cell Extract
16%
Dephosphorylation
16%
Autophosphorylation
16%
Dimerization
16%