The mevalonate pathway as a metabolic requirement for autophagy-implications for growth control, proteostasis, and disease

Teemu P. Miettinen; Mikael Björklund

doi:10.1080/23723556.2016.1143546

The mevalonate pathway as a metabolic requirement for autophagy-implications for growth control, proteostasis, and disease

Teemu P. Miettinen (Lead / Corresponding author), Mikael Björklund (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences cell size, growth, and proteostasis by regulating basal autophagic flux through geranylgeranylation of the small GTPase RAB11. The control of autophagy by the mevalonate/cholesterol pathway has potential implications for statin toxicity, inflammation, cancer, and neurodegenerative diseases.

Original language	English
Article number	e1143546
Number of pages	3
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	3
Early online date	18 Feb 2016
DOIs	https://doi.org/10.1080/23723556.2016.1143546
Publication status	Published - 2016

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10.1080/23723556.2016.1143546

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The mevalonate pathway as a metabolic requirement for autophagy-implications for growth control, proteostasis, and disease

Abstract

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