The mevalonate pathway as a metabolic requirement for autophagy-implications for growth control, proteostasis, and disease

Teemu P. Miettinen (Lead / Corresponding author), Mikael Björklund (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences cell size, growth, and proteostasis by regulating basal autophagic flux through geranylgeranylation of the small GTPase RAB11. The control of autophagy by the mevalonate/cholesterol pathway has potential implications for statin toxicity, inflammation, cancer, and neurodegenerative diseases.

Original languageEnglish
Article numbere1143546
Number of pages3
JournalMolecular and Cellular Oncology
Volume3
Issue number3
Early online date18 Feb 2016
DOIs
Publication statusPublished - 2016

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