The mevalonate pathway as a metabolic requirement for autophagy-implications for growth control, proteostasis, and disease

Teemu P. Miettinen (Lead / Corresponding author), Mikael Björklund (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)

    Abstract

    Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences cell size, growth, and proteostasis by regulating basal autophagic flux through geranylgeranylation of the small GTPase RAB11. The control of autophagy by the mevalonate/cholesterol pathway has potential implications for statin toxicity, inflammation, cancer, and neurodegenerative diseases.

    Original languageEnglish
    Article numbere1143546
    Number of pages3
    JournalMolecular and Cellular Oncology
    Volume3
    Issue number3
    Early online date18 Feb 2016
    DOIs
    Publication statusPublished - 2016

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