The minimum M3-M4 loop length of neurotransmitteractivated pentameric receptors is critical for the structural integrity of cytoplasmic portals

TY - JOUR

T1 - The minimum M3-M4 loop length of neurotransmitteractivated pentameric receptors is critical for the structural integrity of cytoplasmic portals

AU - Baptista-Hon, Daniel T.

AU - Deeb, Tarek Z.

AU - Lambert, Jeremy J.

AU - Peters, John A.

AU - Hales, Tim G.

PY - 2013/7/26

Y1 - 2013/7/26

N2 - Background: Residue 436 within 5-HT3A cytoplasmic portals determines single channel conductance (?) and rectification. Results: M3-M4 loop truncation to 75 residues spared inward rectification; truncation to 70 abolished rectification and increased -. Human Cys-loop neurotransmitter receptor M3-M4 loops all exceed 70 residues. Conclusion: M3-M4 lengths of >70 are critical. Significance: Cytoplasmic portals may be essential for normal function of Cys-loop neurotransmitter receptors.

AB - Background: Residue 436 within 5-HT3A cytoplasmic portals determines single channel conductance (?) and rectification. Results: M3-M4 loop truncation to 75 residues spared inward rectification; truncation to 70 abolished rectification and increased -. Human Cys-loop neurotransmitter receptor M3-M4 loops all exceed 70 residues. Conclusion: M3-M4 lengths of >70 are critical. Significance: Cytoplasmic portals may be essential for normal function of Cys-loop neurotransmitter receptors.

UR - https://www.scopus.com/pages/publications/84881235747

U2 - 10.1074/jbc.M113.481689

DO - 10.1074/jbc.M113.481689

M3 - Article

C2 - 23740249

AN - SCOPUS:84881235747

SN - 0021-9258

VL - 288

SP - 21558

EP - 21568

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 30

ER -