The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

Paul Dent, Alain Lavoinne, Sara Nakielny, F. Barry Caudwell, Peter Watt, Philip Cohen

    Research output: Contribution to journalArticlepeer-review

    396 Citations (Scopus)

    Abstract

    The ability of insulin to promote the phosphoryl-ation of some proteins and the dephosphorylation of others is paradoxical. An insulin-stimulated protein kinase is shown to activate the type-1 protein phosphatase that controls glycogen metabolism, by phosphorylating its regulatory subunit at a specific serine. Furthermore, the phosphorylation of this residue is stimulated by insulin in vivo. Increased and decreased phosphorylation of proteins by insulin can therefore be explained through the same basic underlying mechanism.

    Original languageEnglish
    Pages (from-to)302-308
    Number of pages7
    JournalNature
    Volume348
    Issue number6299
    DOIs
    Publication statusPublished - 22 Nov 1990

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