The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder: a critical review

Rachel X A  Petrie; Ian C  Reid; Caroline A  Stewart

The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder: a critical review

Rachel X A Petrie, Ian C Reid, Caroline A Stewart

Research output: Contribution to journal › Review article › peer-review

Abstract

The roles of the N-methyl-D-aspartate (NMDA) receptor and NMDA receptor-mediated synaptic plasticity are reviewed in the context of depressive disorder and its treatment. The mode of action of antidepressant treatment is poorly understood. Animal studies have suggested that many antidepressant drugs show activity at the NMDA receptor and that NMDA antagonists have antidepressant profiles in preclinical models of depression. A post-mortem study in humans has suggested that certain binding characteristics of the NMDA receptor may be down-regulated in the brains of suicide victims. "Depressogenic" stressors in animals and chronic administration of antidepressant agents perturb NMDA-dependent synaptic plasticity in the hippocampus. (C) 2000 Elsevier Science Inc. All rights reserved.

Original language	English
Pages (from-to)	11-25
Number of pages	15
Journal	Pharmacology & Therapeutics
Volume	87
Issue number	1
Publication status	Published - Jul 2000

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title = "The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder: a critical review",

abstract = "The roles of the N-methyl-D-aspartate (NMDA) receptor and NMDA receptor-mediated synaptic plasticity are reviewed in the context of depressive disorder and its treatment. The mode of action of antidepressant treatment is poorly understood. Animal studies have suggested that many antidepressant drugs show activity at the NMDA receptor and that NMDA antagonists have antidepressant profiles in preclinical models of depression. A post-mortem study in humans has suggested that certain binding characteristics of the NMDA receptor may be down-regulated in the brains of suicide victims. {"}Depressogenic{"} stressors in animals and chronic administration of antidepressant agents perturb NMDA-dependent synaptic plasticity in the hippocampus. (C) 2000 Elsevier Science Inc. All rights reserved.",

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year = "2000",

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T1 - The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder

T2 - a critical review

AU - Petrie, Rachel X A

AU - Reid, Ian C

AU - Stewart, Caroline A

PY - 2000/7

Y1 - 2000/7

N2 - The roles of the N-methyl-D-aspartate (NMDA) receptor and NMDA receptor-mediated synaptic plasticity are reviewed in the context of depressive disorder and its treatment. The mode of action of antidepressant treatment is poorly understood. Animal studies have suggested that many antidepressant drugs show activity at the NMDA receptor and that NMDA antagonists have antidepressant profiles in preclinical models of depression. A post-mortem study in humans has suggested that certain binding characteristics of the NMDA receptor may be down-regulated in the brains of suicide victims. "Depressogenic" stressors in animals and chronic administration of antidepressant agents perturb NMDA-dependent synaptic plasticity in the hippocampus. (C) 2000 Elsevier Science Inc. All rights reserved.

AB - The roles of the N-methyl-D-aspartate (NMDA) receptor and NMDA receptor-mediated synaptic plasticity are reviewed in the context of depressive disorder and its treatment. The mode of action of antidepressant treatment is poorly understood. Animal studies have suggested that many antidepressant drugs show activity at the NMDA receptor and that NMDA antagonists have antidepressant profiles in preclinical models of depression. A post-mortem study in humans has suggested that certain binding characteristics of the NMDA receptor may be down-regulated in the brains of suicide victims. "Depressogenic" stressors in animals and chronic administration of antidepressant agents perturb NMDA-dependent synaptic plasticity in the hippocampus. (C) 2000 Elsevier Science Inc. All rights reserved.

M3 - Review article

SN - 0163-7258

VL - 87

SP - 11

EP - 25

JO - Pharmacology & Therapeutics

JF - Pharmacology & Therapeutics

IS - 1

ER -

The N-methyl-D-aspartate receptor, synaptic plasticity, and depressive disorder: a critical review

Abstract

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