The neuroscience of hypoglycemia: Studies of the rodent brain

Rory J. McCrimmon, Robert S. Sherwin

    Research output: Contribution to journalBook/Film/Article reviewpeer-review


    Individuals with type 1 diabetes suffer repeated episodes of insulin-induced hypoglycemia, reflecting both their need for insulin replacement (exogenously delivered and unregulated) and defects in many aspects of the neuroendocrine
    counterregulatory response to hypoglycemia. In this review we examine the mechanisms by which the brain detects falling glucose and initiates a counterregulatory hormone defense response. We propose that glucose is monitored
    through a network of central and peripheral glucose sensors, with specialized neurons in each region using glucose-sensing mechanisms very similar to those of the pancreatic ß- and a-cells.
    Original languageEnglish
    Pages (from-to)226-233
    Number of pages8
    JournalInternational Diabetes Monitor
    Issue number6
    Publication statusPublished - 2009


    • Hypoglycemia


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