Abstract
Individuals with type 1 diabetes suffer repeated episodes of insulin-induced hypoglycemia, reflecting both their need for insulin replacement (exogenously delivered and unregulated) and defects in many aspects of the neuroendocrine
counterregulatory response to hypoglycemia. In this review we examine the mechanisms by which the brain detects falling glucose and initiates a counterregulatory hormone defense response. We propose that glucose is monitored
through a network of central and peripheral glucose sensors, with specialized neurons in each region using glucose-sensing mechanisms very similar to those of the pancreatic ß- and a-cells.
counterregulatory response to hypoglycemia. In this review we examine the mechanisms by which the brain detects falling glucose and initiates a counterregulatory hormone defense response. We propose that glucose is monitored
through a network of central and peripheral glucose sensors, with specialized neurons in each region using glucose-sensing mechanisms very similar to those of the pancreatic ß- and a-cells.
| Original language | English |
|---|---|
| Pages (from-to) | 226-233 |
| Number of pages | 8 |
| Journal | International Diabetes Monitor |
| Volume | 21 |
| Issue number | 6 |
| Publication status | Published - 2009 |
Keywords
- Hypoglycemia
