The neurotoxicity of the venom phospholipases A 2 , notexin and taipoxin

J. B. Harris, B. D. Grubb, C. A. Maltin, R. Dixon

    Research output: Contribution to journalArticle

    90 Citations (Scopus)

    Abstract

    The presynaptically active, toxic phospholipases known as notexin and taipoxin are principal components of the venom of the Australian tiger snake and the Australian taipan respectively. The inoculation of the toxins into one hind limb of rats caused, within 1 h, the depletion of transmitter from the motor nerve terminals of the soleus muscle. This was followed by the degeneration of the motor nerve terminals and of the axonal cytoskeleton. By 24 h 70% of muscle fibers were completely denervated. Regeneration and functional reinnervation were almost fully restored by 5 days, but collateral innervation was common in the regenerated muscles, and this abnormality persisted for at least 9 months. The data provide an explanation for both the severity of neuromuscular paralysis that can accompany envenoming bites by tiger snakes and taipans and the difficulty experienced by physicians in managing the envenomed subjects. (C) 2000 Academic Press.

    Original languageEnglish
    Pages (from-to)517-526
    Number of pages10
    JournalExperimental Neurology
    Volume161
    Issue number2
    DOIs
    Publication statusPublished - Jan 2000

    Keywords

    • Neurotoxicity
    • Notexin
    • Phospholipases
    • Taipoxin
    • Toxins
    • Venom

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