The NM23 family in development

Aikaterini Bilitou, Julie Watson, Anton Gartner, Shin-ichi Ohnuma

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    The NM23 (non-metastatic 23) family is almost universally conserved across all three domains of life: eubacteria, archaea and eucaryotes. Unicellular organisms possess one NM23 ortholog, whilst vertebrates possess several. Gene multiplication through evolution has been accompanied by structural and functional diversification. Many NM23 orthologs are nucleoside diphosphate kinases (NDP kinases), but some more recently evolved members lack NDP kinase activity and/or display other functions, for instance, acting as protein kinases or transcription factors. These members display overlapping but distinct expression patterns during vertebrate development. In this review, we describe the functional differences and similarities among various NM23 family members. Moreover, we establish orthologous relationships through a phylogenetic analysis of NM23 members across vertebrate species, including Xenopus laevis and zebrafish, primitive chordates and several phyla of invertebrates. Finally, we summarize the involvement of NM23 proteins in development, in particular neural development. Carcinogenesis is a process of misregulated development, and NM23 was initially implicated as a metastasis suppressor. A more detailed understanding of the evolution of the family and its role in vertebrate development will facilitate elucidation of the mechanism of NM23 involvement in human cancer.

    Original languageEnglish
    Pages (from-to)17-33
    Number of pages17
    JournalMolecular and Cellular Biochemistry
    Volume329
    Issue number1-2
    DOIs
    Publication statusPublished - Sep 2009

    Keywords

    • NM23
    • Development
    • Xenopus
    • Neurogenesis
    • NDP kinase
    • NUCLEOSIDE-DIPHOSPHATE KINASE
    • TUMOR-METASTASIS SUPPRESSOR
    • CARCINOMA-CELL-LINE
    • NERVE GROWTH-FACTOR
    • DICTYOSTELIUM-DISCOIDEUM
    • DIFFERENTIAL EXPRESSION
    • DROSOPHILA DEVELOPMENT
    • MOUSE ORGANOGENESIS
    • ENZYMATIC-ACTIVITY
    • CANCER METASTASIS

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