The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

Michale McMaghon, Simon A. Chanas, Colin J. Henderson, C. Roland Wolf, Masayuki Yamamoto, John D. Hayes

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    Abstract

    Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (ARF). It also contributes to the inducible expression of certain members of the ARE-gene battery. Under normal dietary conditions, the expression of class Alpha and class Mu glutathione S-transferase (GST) isoenzymes and NAD(P)H:quinone oxidoreductase (NQO) in the liver and small intestine is reduced significantly in nrf 2 (-/-) mice. Administration of chemopreventive agents to wildtype mice can result in marked induction of hepatic and intestinal GST and NQO. However, the extent of induction of these detoxication enzymes in the nrf 2 knockout mouse is variable, suggesting gene-specific effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)291-294
    Number of pages4
    JournalChemico-Biological Interactions
    Volume133
    Issue number1-3
    DOIs
    Publication statusPublished - 28 Feb 2001

    Keywords

    • Nrf2
    • Cancer chemoprevention
    • Glutathione S-transferase
    • NAD(P)H
    • Quinone oxidoreductase

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