The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

Michale McMaghon; Simon A. Chanas; Colin J.  Henderson; C. Roland  Wolf; Masayuki Yamamoto; John D. Hayes

doi:10.1016/S0009-2797(00)00216-7

The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

Michale McMaghon, Simon A. Chanas, Colin J. Henderson, C. Roland Wolf, Masayuki Yamamoto, John D. Hayes

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (ARF). It also contributes to the inducible expression of certain members of the ARE-gene battery. Under normal dietary conditions, the expression of class Alpha and class Mu glutathione S-transferase (GST) isoenzymes and NAD(P)H:quinone oxidoreductase (NQO) in the liver and small intestine is reduced significantly in nrf 2 (-/-) mice. Administration of chemopreventive agents to wildtype mice can result in marked induction of hepatic and intestinal GST and NQO. However, the extent of induction of these detoxication enzymes in the nrf 2 knockout mouse is variable, suggesting gene-specific effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	291-294
Number of pages	4
Journal	Chemico-Biological Interactions
Volume	133
Issue number	1-3
DOIs	https://doi.org/10.1016/S0009-2797(00)00216-7
Publication status	Published - 28 Feb 2001

Keywords

Nrf2
Cancer chemoprevention
Glutathione S-transferase
NAD(P)H
Quinone oxidoreductase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0009-2797(00)00216-7

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McMaghon, M., Chanas, S. A., Henderson, C. J., Wolf, C. R., Yamamoto, M., & Hayes, J. D. (2001). The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents. Chemico-Biological Interactions, 133(1-3), 291-294. https://doi.org/10.1016/S0009-2797(00)00216-7

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title = "The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents",

abstract = "Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (ARF). It also contributes to the inducible expression of certain members of the ARE-gene battery. Under normal dietary conditions, the expression of class Alpha and class Mu glutathione S-transferase (GST) isoenzymes and NAD(P)H:quinone oxidoreductase (NQO) in the liver and small intestine is reduced significantly in nrf 2 (-/-) mice. Administration of chemopreventive agents to wildtype mice can result in marked induction of hepatic and intestinal GST and NQO. However, the extent of induction of these detoxication enzymes in the nrf 2 knockout mouse is variable, suggesting gene-specific effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.",

keywords = "Nrf2, Cancer chemoprevention, Glutathione S-transferase, NAD(P)H, Quinone oxidoreductase",

author = "Michale McMaghon and Chanas, {Simon A.} and Henderson, {Colin J.} and Wolf, {C. Roland} and Masayuki Yamamoto and Hayes, {John D.}",

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language = "English",

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McMaghon, M, Chanas, SA, Henderson, CJ , Wolf, CR, Yamamoto, M & Hayes, JD 2001, 'The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents', Chemico-Biological Interactions, vol. 133, no. 1-3, pp. 291-294. https://doi.org/10.1016/S0009-2797(00)00216-7

The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents. / McMaghon, Michale; Chanas, Simon A.; Henderson, Colin J. et al.
In: Chemico-Biological Interactions, Vol. 133, No. 1-3, 28.02.2001, p. 291-294.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

AU - McMaghon, Michale

AU - Chanas, Simon A.

AU - Henderson, Colin J.

AU - Wolf, C. Roland

AU - Yamamoto, Masayuki

AU - Hayes, John D.

PY - 2001/2/28

Y1 - 2001/2/28

N2 - Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (ARF). It also contributes to the inducible expression of certain members of the ARE-gene battery. Under normal dietary conditions, the expression of class Alpha and class Mu glutathione S-transferase (GST) isoenzymes and NAD(P)H:quinone oxidoreductase (NQO) in the liver and small intestine is reduced significantly in nrf 2 (-/-) mice. Administration of chemopreventive agents to wildtype mice can result in marked induction of hepatic and intestinal GST and NQO. However, the extent of induction of these detoxication enzymes in the nrf 2 knockout mouse is variable, suggesting gene-specific effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

AB - Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (ARF). It also contributes to the inducible expression of certain members of the ARE-gene battery. Under normal dietary conditions, the expression of class Alpha and class Mu glutathione S-transferase (GST) isoenzymes and NAD(P)H:quinone oxidoreductase (NQO) in the liver and small intestine is reduced significantly in nrf 2 (-/-) mice. Administration of chemopreventive agents to wildtype mice can result in marked induction of hepatic and intestinal GST and NQO. However, the extent of induction of these detoxication enzymes in the nrf 2 knockout mouse is variable, suggesting gene-specific effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

KW - Nrf2

KW - Cancer chemoprevention

KW - Glutathione S-transferase

KW - NAD(P)H

KW - Quinone oxidoreductase

U2 - 10.1016/S0009-2797(00)00216-7

DO - 10.1016/S0009-2797(00)00216-7

M3 - Article

SN - 0009-2797

VL - 133

SP - 291

EP - 294

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

IS - 1-3

ER -

The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents

Abstract

Keywords

UN SDGs

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