The Nucleolus

A. I. Lamond, T. Ly, S. Hutten, A. Nicolas

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the 'multifunctional' or 'plurifunctional' nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

Original languageEnglish
Title of host publicationFunctional Cell Biology
PublisherElsevier Inc.
Pages254-269
Number of pages16
Volume3
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Cajal body
  • Nuclear bodies
  • Nucleolus
  • P53
  • Proteomics
  • RDNA transcription
  • Regulation of gene expression
  • Ribosome
  • RNA pol I
  • RRNA
  • Stress sensor

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