The Nucleolus

A. I. Lamond, T. Ly, S. Hutten, A. Nicolas

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the 'multifunctional' or 'plurifunctional' nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

    Original languageEnglish
    Title of host publicationFunctional Cell Biology
    PublisherElsevier Inc.
    Pages254-269
    Number of pages16
    Volume3
    ISBN (Electronic)9780123944474
    ISBN (Print)9780123947963
    DOIs
    Publication statusPublished - 1 Jan 2016

    Keywords

    • Cajal body
    • Nuclear bodies
    • Nucleolus
    • P53
    • Proteomics
    • RDNA transcription
    • Regulation of gene expression
    • Ribosome
    • RNA pol I
    • RRNA
    • Stress sensor

    ASJC Scopus subject areas

    • General Medicine

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