The Nucleolus

A. I. Lamond; T. Ly; S. Hutten; A. Nicolas

doi:10.1016/B978-0-12-394447-4.30036-0

The Nucleolus

A. I. Lamond, T. Ly, S. Hutten, A. Nicolas

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

Abstract

The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the 'multifunctional' or 'plurifunctional' nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

Original language	English
Title of host publication	Functional Cell Biology
Publisher	Elsevier
Pages	254-269
Number of pages	16
Volume	3
ISBN (Electronic)	9780123944474
ISBN (Print)	9780123947963
DOIs	https://doi.org/10.1016/B978-0-12-394447-4.30036-0
Publication status	Published - 1 Jan 2016

Keywords

Cajal body
Nuclear bodies
Nucleolus
P53
Proteomics
RDNA transcription
Regulation of gene expression
Ribosome
RNA pol I
RRNA
Stress sensor

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-394447-4.30036-0

Cite this

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title = "The Nucleolus",

abstract = "The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the 'multifunctional' or 'plurifunctional' nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.",

keywords = "Cajal body, Nuclear bodies, Nucleolus, P53, Proteomics, RDNA transcription, Regulation of gene expression, Ribosome, RNA pol I, RRNA, Stress sensor",

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language = "English",

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volume = "3",

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T1 - The Nucleolus

AU - Lamond, A. I.

AU - Ly, T.

AU - Hutten, S.

AU - Nicolas, A.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the 'multifunctional' or 'plurifunctional' nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

AB - The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the 'multifunctional' or 'plurifunctional' nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

KW - Cajal body

KW - Nuclear bodies

KW - Nucleolus

KW - P53

KW - Proteomics

KW - RDNA transcription

KW - Regulation of gene expression

KW - Ribosome

KW - RNA pol I

KW - RRNA

KW - Stress sensor

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U2 - 10.1016/B978-0-12-394447-4.30036-0

DO - 10.1016/B978-0-12-394447-4.30036-0

M3 - Chapter

SN - 9780123947963

VL - 3

SP - 254

EP - 269

BT - Functional Cell Biology

PB - Elsevier

ER -

The Nucleolus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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