The Nucleolus

Angus I. Lamond, Tony Ly, Saskia Hutten, Armel Nicolas

    Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary


    The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the “multifunctional” or “plurifunctional” nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

    Original languageEnglish
    Title of host publicationEncyclopedia of Cell Biology
    EditorsRalph A. Bradshaw, Gerald W. Hart, Philip D. Stahl, Michael L. Dustin
    Place of PublicationLondon
    Number of pages18
    ISBN (Electronic)9780128216248
    Publication statusPublished - 2023


    • Cajal body
    • Nuclear bodies
    • Nucleolus
    • P53
    • Proteomics
    • RDNA transcription
    • Regulation of gene expression
    • Ribosome
    • RNA pol I
    • RRNA
    • Stress sensor

    ASJC Scopus subject areas

    • General Biochemistry,Genetics and Molecular Biology


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