The Nucleolus

Angus I. Lamond; Tony Ly; Saskia Hutten; Armel Nicolas

doi:10.1016/B978-0-12-821618-7.00222-4

The Nucleolus

Angus I. Lamond, Tony Ly, Saskia Hutten, Armel Nicolas

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

Abstract

The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the “multifunctional” or “plurifunctional” nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Editors	Ralph A. Bradshaw, Gerald W. Hart, Philip D. Stahl, Michael L. Dustin
Place of Publication	London
Publisher	Elsevier
Pages	26-43
Number of pages	18
Volume	5
Edition	2nd
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00222-4
Publication status	Published - 2023

Keywords

Cajal body
Nuclear bodies
Nucleolus
P53
Proteomics
RDNA transcription
Regulation of gene expression
Ribosome
RNA pol I
RRNA
Stress sensor

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-821618-7.00222-4Licence: Elsevier User Licence

Cite this

@inbook{740fd1ec4da54d43882e84bd46d54bdc,

title = "The Nucleolus",

abstract = "The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the “multifunctional” or “plurifunctional” nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.",

keywords = "Cajal body, Nuclear bodies, Nucleolus, P53, Proteomics, RDNA transcription, Regulation of gene expression, Ribosome, RNA pol I, RRNA, Stress sensor",

author = "Lamond, {Angus I.} and Tony Ly and Saskia Hutten and Armel Nicolas",

year = "2023",

doi = "10.1016/B978-0-12-821618-7.00222-4",

language = "English",

volume = "5",

pages = "26--43",

editor = "Bradshaw, {Ralph A.} and Hart, {Gerald W.} and Stahl, {Philip D.} and Dustin, {Michael L.}",

booktitle = "Encyclopedia of Cell Biology",

publisher = "Elsevier",

address = "Netherlands",

edition = "2nd",

}

TY - CHAP

T1 - The Nucleolus

AU - Lamond, Angus I.

AU - Ly, Tony

AU - Hutten, Saskia

AU - Nicolas, Armel

PY - 2023

Y1 - 2023

N2 - The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the “multifunctional” or “plurifunctional” nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

AB - The nucleolus is a prominent structure within the interphase nucleus that is visible by conventional light microscopy. Nucleoli are highly dynamic, polymorphic structures. Nucleolar function and architecture are temporally and developmentally regulated in response to changing cellular and environmental conditions. The function of the nucleolus was first identified as being essential in coordinating ribosomal subunit biogenesis. However, more recent advances in nucleolar research have revealed it to have additional important roles in other aspects of cell biology and in human disease. These results have shaped the current view of the “multifunctional” or “plurifunctional” nucleolus. This article will provide an overview of nucleolar architecture, its many functions, and its dynamic behavior.

KW - Cajal body

KW - Nuclear bodies

KW - Nucleolus

KW - P53

KW - Proteomics

KW - RDNA transcription

KW - Regulation of gene expression

KW - Ribosome

KW - RNA pol I

KW - RRNA

KW - Stress sensor

UR - http://www.scopus.com/inward/record.url?scp=85158978387&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-821618-7.00222-4

DO - 10.1016/B978-0-12-821618-7.00222-4

M3 - Entry for encyclopedia/dictionary

AN - SCOPUS:85158978387

VL - 5

SP - 26

EP - 43

BT - Encyclopedia of Cell Biology

A2 - Bradshaw, Ralph A.

A2 - Hart, Gerald W.

A2 - Stahl, Philip D.

A2 - Dustin, Michael L.

PB - Elsevier

CY - London

ER -

The Nucleolus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this