The Nucleolus under Stress

Severine Boulon, Belinda J. Westman, Saskia Hutten, Francois-Michel Boisvert, Angus I. Lamond

    Research output: Contribution to journalReview articlepeer-review

    619 Citations (Scopus)

    Abstract

    Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to recover. Stress also often leads to reorganization of nuclear architecture, reflecting the simultaneous inhibition of major nuclear pathways (e.g., replication and transcription) and activation of specific stress responses (e.g., DNA repair). In this review, we focus on how two nuclear organelles, the nucleolus and the Cajal body, respond to stress. The nucleolus senses stress and is a central hub for coordinating the stress response. We review nucleolar function in the stress-induced regulation of p53 and the specific changes in nucleolar morphology and composition that occur upon stress. Crosstalk between nucleoli and CBs is also discussed in the context of stress responses.

    Original languageEnglish
    Pages (from-to)216-227
    Number of pages12
    JournalMolecular Cell
    Volume40
    Issue number2
    DOIs
    Publication statusPublished - 22 Oct 2010

    Keywords

    • POLYMERASE-I TRANSCRIPTION
    • ADENOVIRUS-INFECTED CELLS
    • RIBOSOMAL-RNA SYNTHESIS
    • CAJAL BODIES
    • COILED BODIES
    • DNA-DAMAGE
    • PROTEOMICS ANALYSIS
    • P53
    • PROTEIN
    • NUCLEAR

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