The nuts and bolts of AGC protein kinases

Laura R. Pearce, David Komander, Dario R. Alessi

    Research output: Contribution to journalReview articlepeer-review

    1029 Citations (Scopus)


    The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K, RSK, MSK, PDK1 and GRK) as well as many less well-studied enzymes (such as SGK, NDR, LATS, CRIK, SGK494, PRKX, PRKY and MAST). Research has shed new light onto the architecture and regulatory mechanisms of these kinases. In addition, AGC kinases mediate diverse and important cellular functions, and their mutation and/or dysregulation contributes to the pathogenesis of many human diseases, including cancer and diabetes.

    Original languageEnglish
    Pages (from-to)9-22
    Number of pages14
    JournalNature Reviews Molecular Cell Biology
    Issue number1
    Publication statusPublished - Jan 2010


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