The nuts and bolts of AGC protein kinases

Laura R. Pearce; David Komander; Dario R. Alessi

doi:10.1038/nrm2822

The nuts and bolts of AGC protein kinases

Laura R. Pearce
, David Komander
, Dario R. Alessi

Research output: Contribution to journal › Review article › peer-review

1118 Citations (Scopus)

Abstract

The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K, RSK, MSK, PDK1 and GRK) as well as many less well-studied enzymes (such as SGK, NDR, LATS, CRIK, SGK494, PRKX, PRKY and MAST). Research has shed new light onto the architecture and regulatory mechanisms of these kinases. In addition, AGC kinases mediate diverse and important cellular functions, and their mutation and/or dysregulation contributes to the pathogenesis of many human diseases, including cancer and diabetes.

Original language	English
Pages (from-to)	9-22
Number of pages	14
Journal	Nature Reviews Molecular Cell Biology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/nrm2822
Publication status	Published - Jan 2010

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10.1038/nrm2822

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abstract = "The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K, RSK, MSK, PDK1 and GRK) as well as many less well-studied enzymes (such as SGK, NDR, LATS, CRIK, SGK494, PRKX, PRKY and MAST). Research has shed new light onto the architecture and regulatory mechanisms of these kinases. In addition, AGC kinases mediate diverse and important cellular functions, and their mutation and/or dysregulation contributes to the pathogenesis of many human diseases, including cancer and diabetes.",

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The nuts and bolts of AGC protein kinases

Abstract

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