The osmotic responses of Saccharomyces cerevisiae in K+-depleted medium

Amanda J. Meikle, Robert H. Reed, Geoffrey M. Gadd (Lead / Corresponding author)

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    7 Citations (Scopus)


    Saccharomyces cerevisiae showed reduced growth in a K+-depleted medium but was still capable of synthesizing and accumulating glycerol in the presence of 2.28% (w/v) NaCl; glycerol levels were similar in both K+-replete and K+-depleted media. The activity of glycerol-3-phosphate dehydrogenase, a key enzyme of glycerol synthesis, was inhibited to a similar extent by exogenous K+ and Na+ although such effects may be modified in vivo due to ionic compartmentation within the vacuole. These results indicate that exogenous K+ does not play a significant role in the initiation of glycerol synthesis in osmotically-stressed yeast.

    Original languageEnglish
    Pages (from-to)89-94
    Number of pages6
    JournalFEMS Microbiology Letters
    Issue number1
    Publication statusPublished - 1 Feb 1991


    • Glycerol
    • Glycerol-3-phosphate dehydrogenase
    • Potassium
    • Saccharomyces cerevisiae

    ASJC Scopus subject areas

    • Microbiology
    • Molecular Biology
    • Genetics


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