The p53 tumour suppressor gene

R. J. C. Steele, A. M. Thompson, P. A. Hall, D. P. Lane

    Research output: Contribution to journalArticle

    173 Citations (Scopus)

    Abstract

    Abnormalities of the p53 tumour suppressor gene are thought to be central to the development of a high proportion of human tumours. This article reviews current understanding of its function and potential clinical significance.
    Original languageEnglish
    Pages (from-to)1460-1467
    Number of pages8
    JournalBritish Journal of Surgery
    Volume85
    Issue number11
    DOIs
    Publication statusPublished - 1998

    Keywords

    • Apoptosis
    • Cell Division
    • Gene Expression Regulation, Neoplastic
    • Genes, p53
    • Genetic Therapy
    • Humans
    • Mutation
    • Neoplasms
    • Tumor Suppressor Protein p53

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