The p53 tumour suppressor gene

R. J. C. Steele; A. M. Thompson; P. A.  Hall; D. P. Lane

doi:10.1046/j.1365-2168.1998.00910.x

The p53 tumour suppressor gene

R. J. C. Steele
, A. M. Thompson
, P. A. Hall
, D. P. Lane

Research output: Contribution to journal › Article › peer-review

193 Citations (Scopus)

Abstract

Abnormalities of the p53 tumour suppressor gene are thought to be central to the development of a high proportion of human tumours. This article reviews current understanding of its function and potential clinical significance.

Original language	English
Pages (from-to)	1460-1467
Number of pages	8
Journal	British Journal of Surgery
Volume	85
Issue number	11
DOIs	https://doi.org/10.1046/j.1365-2168.1998.00910.x
Publication status	Published - 1998

Keywords

Apoptosis
Cell Division
Gene Expression Regulation, Neoplastic
Genes, p53
Genetic Therapy
Humans
Mutation
Neoplasms
Tumor Suppressor Protein p53

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10.1046/j.1365-2168.1998.00910.x

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@article{f60a6cd1b99049949546a17680a0d870,

title = "The p53 tumour suppressor gene",

abstract = "Abnormalities of the p53 tumour suppressor gene are thought to be central to the development of a high proportion of human tumours. This article reviews current understanding of its function and potential clinical significance.",

keywords = "Apoptosis, Cell Division, Gene Expression Regulation, Neoplastic, Genes, p53, Genetic Therapy, Humans, Mutation, Neoplasms, Tumor Suppressor Protein p53",

author = "Steele, \{R. J. C.\} and Thompson, \{A. M.\} and Hall, \{P. A.\} and Lane, \{D. P.\}",

year = "1998",

doi = "10.1046/j.1365-2168.1998.00910.x",

language = "English",

volume = "85",

pages = "1460--1467",

journal = "British Journal of Surgery",

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publisher = "Oxford University Press",

number = "11",

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T1 - The p53 tumour suppressor gene

AU - Steele, R. J. C.

AU - Thompson, A. M.

AU - Hall, P. A.

AU - Lane, D. P.

PY - 1998

Y1 - 1998

N2 - Abnormalities of the p53 tumour suppressor gene are thought to be central to the development of a high proportion of human tumours. This article reviews current understanding of its function and potential clinical significance.

AB - Abnormalities of the p53 tumour suppressor gene are thought to be central to the development of a high proportion of human tumours. This article reviews current understanding of its function and potential clinical significance.

KW - Apoptosis

KW - Cell Division

KW - Gene Expression Regulation, Neoplastic

KW - Genes, p53

KW - Genetic Therapy

KW - Humans

KW - Mutation

KW - Neoplasms

KW - Tumor Suppressor Protein p53

U2 - 10.1046/j.1365-2168.1998.00910.x

DO - 10.1046/j.1365-2168.1998.00910.x

M3 - Article

C2 - 9823903

SN - 0007-1323

VL - 85

SP - 1460

EP - 1467

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 11

ER -

The p53 tumour suppressor gene

Abstract

Keywords

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