The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients

C. A. Harwood, A. E. Toland, C. M. Proby, S. Euvrard, G. F. L. Hofbauer, M. Tommasino, J. N. Bouwes-Bavinck (Lead / Corresponding author), KeraCon Consortium

    Research output: Contribution to journalReview articlepeer-review

    27 Citations (Scopus)
    190 Downloads (Pure)

    Abstract

    The pathogenesis of keratinocyte carcinoma following organ transplantation is multifactorial, and recent evidence suggests a complex and often synergistic interplay between the carcinogenic effects of ultraviolet radiation, compromised immune surveillance, direct pro- and anticarcinogenic effects of drugs, oncogenic viruses (in particular, beta-genus human papillomaviruses) and host genetic susceptibility factors. We present an overview of those factors for which there is currently the most convincing evidence and highlight important gaps in our knowledge. In particular, a clear understanding of the interdependence and relative contributions of these co-factors is currently lacking, yet has important implications for rational development of clinically relevant biomarkers and targeted strategies for treatment and prevention of post-transplant keratinocyte cancers.

    Original languageEnglish
    Pages (from-to)1217-1224
    Number of pages8
    JournalBritish Journal of Dermatology
    Volume177
    Issue number5
    Early online date30 Oct 2017
    DOIs
    Publication statusPublished - Nov 2017

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