The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients

C. A. Harwood; A. E. Toland; C. M. Proby; S. Euvrard; G. F. L. Hofbauer; M. Tommasino; J. N. Bouwes-Bavinck; KeraCon Consortium

doi:10.1111/bjd.15956

The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients

C. A. Harwood, A. E. Toland, C. M. Proby, S. Euvrard, G. F. L. Hofbauer, M. Tommasino, J. N. Bouwes-Bavinck (Lead / Corresponding author), KeraCon Consortium

Research output: Contribution to journal › Review article › peer-review

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Abstract

The pathogenesis of keratinocyte carcinoma following organ transplantation is multifactorial, and recent evidence suggests a complex and often synergistic interplay between the carcinogenic effects of ultraviolet radiation, compromised immune surveillance, direct pro- and anticarcinogenic effects of drugs, oncogenic viruses (in particular, beta-genus human papillomaviruses) and host genetic susceptibility factors. We present an overview of those factors for which there is currently the most convincing evidence and highlight important gaps in our knowledge. In particular, a clear understanding of the interdependence and relative contributions of these co-factors is currently lacking, yet has important implications for rational development of clinically relevant biomarkers and targeted strategies for treatment and prevention of post-transplant keratinocyte cancers.

Original language	English
Pages (from-to)	1217-1224
Number of pages	8
Journal	British Journal of Dermatology
Volume	177
Issue number	5
Early online date	30 Oct 2017
DOIs	https://doi.org/10.1111/bjd.15956
Publication status	Published - Nov 2017

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title = "The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients",

abstract = "The pathogenesis of keratinocyte carcinoma following organ transplantation is multifactorial, and recent evidence suggests a complex and often synergistic interplay between the carcinogenic effects of ultraviolet radiation, compromised immune surveillance, direct pro- and anticarcinogenic effects of drugs, oncogenic viruses (in particular, beta-genus human papillomaviruses) and host genetic susceptibility factors. We present an overview of those factors for which there is currently the most convincing evidence and highlight important gaps in our knowledge. In particular, a clear understanding of the interdependence and relative contributions of these co-factors is currently lacking, yet has important implications for rational development of clinically relevant biomarkers and targeted strategies for treatment and prevention of post-transplant keratinocyte cancers.",

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AU - Harwood, C. A.

AU - Toland, A. E.

AU - Proby, C. M.

AU - Euvrard, S.

AU - Hofbauer, G. F. L.

AU - Tommasino, M.

AU - Bouwes-Bavinck, J. N.

AU - KeraCon Consortium

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AB - The pathogenesis of keratinocyte carcinoma following organ transplantation is multifactorial, and recent evidence suggests a complex and often synergistic interplay between the carcinogenic effects of ultraviolet radiation, compromised immune surveillance, direct pro- and anticarcinogenic effects of drugs, oncogenic viruses (in particular, beta-genus human papillomaviruses) and host genetic susceptibility factors. We present an overview of those factors for which there is currently the most convincing evidence and highlight important gaps in our knowledge. In particular, a clear understanding of the interdependence and relative contributions of these co-factors is currently lacking, yet has important implications for rational development of clinically relevant biomarkers and targeted strategies for treatment and prevention of post-transplant keratinocyte cancers.

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DO - 10.1111/bjd.15956

M3 - Review article

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VL - 177

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EP - 1224

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 5

ER -

The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients

Abstract

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