The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring

Kanheng Zhou, Yan Wang, Kairui Feng, Chunhui Li, Zhihong Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

HIFU is a truly noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the focus to kill the targeted tissue for disease treatment purpose. The mechanical properties of targeted tissue changes before and after treatment, and this change can be accurately detected by shear wave elastography. Hence, shear wave elastography is usually used for monitoring HIFU treatment asynchronously. To improve the low spatial resolution in ultrasound shear wave elastography, and to perform diseases diagnosis, treatment and monitoring in the same system, a new setup that combines HIFU and PhS-OCT system was proposed in this study. This proposed setup could do 1) HIFU treatment when the transducer works at high energy level, 2) ultrasound induced shear wave optical coherence elastography for HIFU treatment asynchronous monitoring when the transducer works at low energy level. Ex-vivo bovine liver tissue was treated at the same energy level for different time (0s, 1s, 5s, 9s) in this research. Elastography was performed on the lesion area of the sample after HIFU treatment, and the elastogram was reconstructed by the time of flight time method. The elastogram results clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time. And the average elasticity of the lesion grows linearly as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment, but also to be used for high-precision-demanded diseases treatment, e.g. nervous disease treatment.

Original languageEnglish
Title of host publicationOptical Elastography and Tissue Biomechanics V
EditorsKirill V. Larin, David D. Sampson
PublisherSPIE-International Society for Optical Engineering
Number of pages7
Volume10496
ISBN (Electronic)9781510614772
ISBN (Print)978-1-5106-1477-2
DOIs
Publication statusPublished - 19 Feb 2018
EventOptical Elastography and Tissue Biomechanics V 2018 - San Francisco, United States
Duration: 27 Jan 201828 Jan 2018

Publication series

NameProceedings of SPIE

Conference

ConferenceOptical Elastography and Tissue Biomechanics V 2018
CountryUnited States
CitySan Francisco
Period27/01/1828/01/18

Fingerprint

Elasticity Imaging Techniques
Optical tomography
Optical Coherence Tomography
tomography
Ultrasonics
Monitoring
Shear waves
Tissue
Electron energy levels
S waves
Transducers
Acoustics
lesions
energy levels
Elasticity
transducers
Needles
Acoustic fields
flight time
Liver

Keywords

  • elastography
  • ex-vivo bovine liver
  • high intensity focused ultrasound (HIFU)
  • phase sensitive optical coherence tomography (PhS-OCT)
  • treatment monitoring

Cite this

Zhou, K., Wang, Y., Feng, K., Li, C., & Huang, Z. (2018). The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring. In K. V. Larin, & D. D. Sampson (Eds.), Optical Elastography and Tissue Biomechanics V (Vol. 10496). [104961E] (Proceedings of SPIE). SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2288503
Zhou, Kanheng ; Wang, Yan ; Feng, Kairui ; Li, Chunhui ; Huang, Zhihong. / The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring. Optical Elastography and Tissue Biomechanics V. editor / Kirill V. Larin ; David D. Sampson. Vol. 10496 SPIE-International Society for Optical Engineering, 2018. (Proceedings of SPIE).
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abstract = "HIFU is a truly noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the focus to kill the targeted tissue for disease treatment purpose. The mechanical properties of targeted tissue changes before and after treatment, and this change can be accurately detected by shear wave elastography. Hence, shear wave elastography is usually used for monitoring HIFU treatment asynchronously. To improve the low spatial resolution in ultrasound shear wave elastography, and to perform diseases diagnosis, treatment and monitoring in the same system, a new setup that combines HIFU and PhS-OCT system was proposed in this study. This proposed setup could do 1) HIFU treatment when the transducer works at high energy level, 2) ultrasound induced shear wave optical coherence elastography for HIFU treatment asynchronous monitoring when the transducer works at low energy level. Ex-vivo bovine liver tissue was treated at the same energy level for different time (0s, 1s, 5s, 9s) in this research. Elastography was performed on the lesion area of the sample after HIFU treatment, and the elastogram was reconstructed by the time of flight time method. The elastogram results clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time. And the average elasticity of the lesion grows linearly as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment, but also to be used for high-precision-demanded diseases treatment, e.g. nervous disease treatment.",
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Zhou, K, Wang, Y, Feng, K, Li, C & Huang, Z 2018, The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring. in KV Larin & DD Sampson (eds), Optical Elastography and Tissue Biomechanics V. vol. 10496, 104961E, Proceedings of SPIE, SPIE-International Society for Optical Engineering, Optical Elastography and Tissue Biomechanics V 2018, San Francisco, United States, 27/01/18. https://doi.org/10.1117/12.2288503

The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring. / Zhou, Kanheng; Wang, Yan; Feng, Kairui; Li, Chunhui; Huang, Zhihong.

Optical Elastography and Tissue Biomechanics V. ed. / Kirill V. Larin; David D. Sampson. Vol. 10496 SPIE-International Society for Optical Engineering, 2018. 104961E (Proceedings of SPIE).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring

AU - Zhou, Kanheng

AU - Wang, Yan

AU - Feng, Kairui

AU - Li, Chunhui

AU - Huang, Zhihong

PY - 2018/2/19

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N2 - HIFU is a truly noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the focus to kill the targeted tissue for disease treatment purpose. The mechanical properties of targeted tissue changes before and after treatment, and this change can be accurately detected by shear wave elastography. Hence, shear wave elastography is usually used for monitoring HIFU treatment asynchronously. To improve the low spatial resolution in ultrasound shear wave elastography, and to perform diseases diagnosis, treatment and monitoring in the same system, a new setup that combines HIFU and PhS-OCT system was proposed in this study. This proposed setup could do 1) HIFU treatment when the transducer works at high energy level, 2) ultrasound induced shear wave optical coherence elastography for HIFU treatment asynchronous monitoring when the transducer works at low energy level. Ex-vivo bovine liver tissue was treated at the same energy level for different time (0s, 1s, 5s, 9s) in this research. Elastography was performed on the lesion area of the sample after HIFU treatment, and the elastogram was reconstructed by the time of flight time method. The elastogram results clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time. And the average elasticity of the lesion grows linearly as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment, but also to be used for high-precision-demanded diseases treatment, e.g. nervous disease treatment.

AB - HIFU is a truly noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the focus to kill the targeted tissue for disease treatment purpose. The mechanical properties of targeted tissue changes before and after treatment, and this change can be accurately detected by shear wave elastography. Hence, shear wave elastography is usually used for monitoring HIFU treatment asynchronously. To improve the low spatial resolution in ultrasound shear wave elastography, and to perform diseases diagnosis, treatment and monitoring in the same system, a new setup that combines HIFU and PhS-OCT system was proposed in this study. This proposed setup could do 1) HIFU treatment when the transducer works at high energy level, 2) ultrasound induced shear wave optical coherence elastography for HIFU treatment asynchronous monitoring when the transducer works at low energy level. Ex-vivo bovine liver tissue was treated at the same energy level for different time (0s, 1s, 5s, 9s) in this research. Elastography was performed on the lesion area of the sample after HIFU treatment, and the elastogram was reconstructed by the time of flight time method. The elastogram results clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time. And the average elasticity of the lesion grows linearly as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment, but also to be used for high-precision-demanded diseases treatment, e.g. nervous disease treatment.

KW - elastography

KW - ex-vivo bovine liver

KW - high intensity focused ultrasound (HIFU)

KW - phase sensitive optical coherence tomography (PhS-OCT)

KW - treatment monitoring

U2 - 10.1117/12.2288503

DO - 10.1117/12.2288503

M3 - Conference contribution

AN - SCOPUS:85045139980

SN - 978-1-5106-1477-2

VL - 10496

T3 - Proceedings of SPIE

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PB - SPIE-International Society for Optical Engineering

ER -

Zhou K, Wang Y, Feng K, Li C, Huang Z. The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring. In Larin KV, Sampson DD, editors, Optical Elastography and Tissue Biomechanics V. Vol. 10496. SPIE-International Society for Optical Engineering. 2018. 104961E. (Proceedings of SPIE). https://doi.org/10.1117/12.2288503