The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring

Kanheng Zhou, Yan Wang, Kairui Feng, Chunhui Li, Zhihong Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

HIFU is a truly noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the focus to kill the targeted tissue for disease treatment purpose. The mechanical properties of targeted tissue changes before and after treatment, and this change can be accurately detected by shear wave elastography. Hence, shear wave elastography is usually used for monitoring HIFU treatment asynchronously. To improve the low spatial resolution in ultrasound shear wave elastography, and to perform diseases diagnosis, treatment and monitoring in the same system, a new setup that combines HIFU and PhS-OCT system was proposed in this study. This proposed setup could do 1) HIFU treatment when the transducer works at high energy level, 2) ultrasound induced shear wave optical coherence elastography for HIFU treatment asynchronous monitoring when the transducer works at low energy level. Ex-vivo bovine liver tissue was treated at the same energy level for different time (0s, 1s, 5s, 9s) in this research. Elastography was performed on the lesion area of the sample after HIFU treatment, and the elastogram was reconstructed by the time of flight time method. The elastogram results clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time. And the average elasticity of the lesion grows linearly as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment, but also to be used for high-precision-demanded diseases treatment, e.g. nervous disease treatment.

Original languageEnglish
Title of host publicationProceedings Volume 10496
Subtitle of host publicationOptical Elastography and Tissue Biomechanics V
EditorsKirill V. Larin, David D. Sampson
PublisherSPIE-International Society for Optical Engineering
Number of pages7
Volume10496
ISBN (Electronic)9781510614789
ISBN (Print)9781510614772
DOIs
Publication statusPublished - 19 Feb 2018
EventOptical Elastography and Tissue Biomechanics V 2018 - San Francisco, United States
Duration: 27 Jan 201828 Jan 2018

Publication series

Name
ISSN (Print)1605-7422
ISSN (Electronic)2410-9045

Conference

ConferenceOptical Elastography and Tissue Biomechanics V 2018
CountryUnited States
CitySan Francisco
Period27/01/1828/01/18

Keywords

  • elastography
  • ex-vivo bovine liver
  • high intensity focused ultrasound (HIFU)
  • phase sensitive optical coherence tomography (PhS-OCT)
  • treatment monitoring

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