The Problem: Relevance, Quality, and Homogeneity of Trial Designs, Outcomes, and Reporting

Gerd Göstemeyer, Colin Levey

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Clinical trials are the cornerstone of evidence-based medicine. By directly comparing different interventions they produce evidence on their relative efficacy and effectiveness This, in turn, can inform secondary research and guideline development to facilitate evidence-based clinical decision making. However, the quality of evidence stemming from clinical trials is frequently poor. Here, the pathway of evidence from basic research to the generation of implementable clinical guidelines will be described. Relevant factors related to trial design and reporting, such as the choice of trial comparators, outcomes and outcome measures, will be described and their influence on evidence synthesis will be discussed. Finally, recommendations on how to improve trials in order to increase their usefulness for evidence generation will be given.

Original languageEnglish
Title of host publicationCaries Excavation
Subtitle of host publication Evolution of Treating Cavitated Carious Lesions
EditorsFalk Schwendicke, Jo Frencken, Nicola Innes
PublisherKarger
Pages146-154
Number of pages9
Volume27
ISBN (Electronic)978-3-318-06369-1
ISBN (Print)978-3-318-06368-4
DOIs
Publication statusPublished - 2018

Publication series

NameMonographs in oral science
ISSN (Print)0077-0892

Fingerprint

Clinical Trials
Guidelines
Evidence-Based Medicine
Research
Outcome Assessment (Health Care)
Clinical Decision-Making

Cite this

Göstemeyer, G., & Levey, C. (2018). The Problem: Relevance, Quality, and Homogeneity of Trial Designs, Outcomes, and Reporting. In F. Schwendicke, J. Frencken, & N. Innes (Eds.), Caries Excavation: Evolution of Treating Cavitated Carious Lesions (Vol. 27, pp. 146-154). (Monographs in oral science). Karger. https://doi.org/10.1159/000487841
Göstemeyer, Gerd ; Levey, Colin. / The Problem : Relevance, Quality, and Homogeneity of Trial Designs, Outcomes, and Reporting. Caries Excavation: Evolution of Treating Cavitated Carious Lesions. editor / Falk Schwendicke ; Jo Frencken ; Nicola Innes. Vol. 27 Karger, 2018. pp. 146-154 (Monographs in oral science).
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Göstemeyer, G & Levey, C 2018, The Problem: Relevance, Quality, and Homogeneity of Trial Designs, Outcomes, and Reporting. in F Schwendicke, J Frencken & N Innes (eds), Caries Excavation: Evolution of Treating Cavitated Carious Lesions. vol. 27, Monographs in oral science, Karger, pp. 146-154. https://doi.org/10.1159/000487841

The Problem : Relevance, Quality, and Homogeneity of Trial Designs, Outcomes, and Reporting. / Göstemeyer, Gerd; Levey, Colin.

Caries Excavation: Evolution of Treating Cavitated Carious Lesions. ed. / Falk Schwendicke; Jo Frencken; Nicola Innes. Vol. 27 Karger, 2018. p. 146-154 (Monographs in oral science).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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AB - Clinical trials are the cornerstone of evidence-based medicine. By directly comparing different interventions they produce evidence on their relative efficacy and effectiveness This, in turn, can inform secondary research and guideline development to facilitate evidence-based clinical decision making. However, the quality of evidence stemming from clinical trials is frequently poor. Here, the pathway of evidence from basic research to the generation of implementable clinical guidelines will be described. Relevant factors related to trial design and reporting, such as the choice of trial comparators, outcomes and outcome measures, will be described and their influence on evidence synthesis will be discussed. Finally, recommendations on how to improve trials in order to increase their usefulness for evidence generation will be given.

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VL - 27

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Göstemeyer G, Levey C. The Problem: Relevance, Quality, and Homogeneity of Trial Designs, Outcomes, and Reporting. In Schwendicke F, Frencken J, Innes N, editors, Caries Excavation: Evolution of Treating Cavitated Carious Lesions. Vol. 27. Karger. 2018. p. 146-154. (Monographs in oral science). https://doi.org/10.1159/000487841