The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

A. Conlin; G. Smith; F. A. Carey; C. R. Wolf; R. J. C. Steele

doi:10.1136/gut.2005.066514

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

A. Conlin, G. Smith, F. A. Carey, C. R. Wolf, R. J. C. Steele

Research output: Contribution to journal › Article › peer-review

222 Citations (Scopus)

Abstract

Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal carcinogenesis. Our group has previously characterised a panel of sporadic colorectal adenocarcinomas for mutations in these three genes and has shown that p53 and K-ras mutations rarely occur in the same colorectal tumour. This suggests that mutations in these genes are on separate pathways to colorectal cancer development and may influence patient prognosis independently.

Original language	English
Pages (from-to)	1283-1286
Number of pages	4
Journal	Gut
Volume	54
Issue number	9
DOIs	https://doi.org/10.1136/gut.2005.066514
Publication status	Published - 2005

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10.1136/gut.2005.066514

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title = "The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma",

abstract = "Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal carcinogenesis. Our group has previously characterised a panel of sporadic colorectal adenocarcinomas for mutations in these three genes and has shown that p53 and K-ras mutations rarely occur in the same colorectal tumour. This suggests that mutations in these genes are on separate pathways to colorectal cancer development and may influence patient prognosis independently.",

author = "A. Conlin and G. Smith and Carey, {F. A.} and Wolf, {C. R.} and Steele, {R. J. C.}",

note = "dc.publisher: BMJ Publishing Group Senior author of paper describing analysis of K-ras, p53, and APC gene mutations and survival in a cohort of colorectal cancer patients. Mutations in p53 and K-ras in the same tumours are rare suggesting that they are on separate pathways to cancer development and may influence prognosis independently. ",

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T1 - The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

AU - Conlin, A.

AU - Smith, G.

AU - Carey, F. A.

AU - Wolf, C. R.

AU - Steele, R. J. C.

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PY - 2005

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N2 - Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal carcinogenesis. Our group has previously characterised a panel of sporadic colorectal adenocarcinomas for mutations in these three genes and has shown that p53 and K-ras mutations rarely occur in the same colorectal tumour. This suggests that mutations in these genes are on separate pathways to colorectal cancer development and may influence patient prognosis independently.

AB - Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal carcinogenesis. Our group has previously characterised a panel of sporadic colorectal adenocarcinomas for mutations in these three genes and has shown that p53 and K-ras mutations rarely occur in the same colorectal tumour. This suggests that mutations in these genes are on separate pathways to colorectal cancer development and may influence patient prognosis independently.

U2 - 10.1136/gut.2005.066514

DO - 10.1136/gut.2005.066514

M3 - Article

SN - 0017-5749

VL - 54

SP - 1283

EP - 1286

JO - Gut

JF - Gut

IS - 9

ER -

The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

Abstract

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