The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

A. Conlin, G. Smith, F. A. Carey, C. R. Wolf, R. J. C. Steele

    Research output: Contribution to journalArticlepeer-review

    168 Citations (Scopus)

    Abstract

    Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal carcinogenesis. Our group has previously characterised a panel of sporadic colorectal adenocarcinomas for mutations in these three genes and has shown that p53 and K-ras mutations rarely occur in the same colorectal tumour. This suggests that mutations in these genes are on separate pathways to colorectal cancer development and may influence patient prognosis independently.
    Original languageEnglish
    Pages (from-to)1283-1286
    Number of pages4
    JournalGut
    Volume54
    Issue number9
    DOIs
    Publication statusPublished - 2005

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