The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

TY - JOUR

T1 - The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma

AU - Conlin, A.

AU - Smith, G.

AU - Carey, F. A.

AU - Wolf, C. R.

AU - Steele, R. J. C.

N1 - dc.publisher: BMJ Publishing Group Senior author of paper describing analysis of K-ras, p53, and APC gene mutations and survival in a cohort of colorectal cancer patients. Mutations in p53 and K-ras in the same tumours are rare suggesting that they are on separate pathways to cancer development and may influence prognosis independently.

PY - 2005

Y1 - 2005

N2 - Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal carcinogenesis. Our group has previously characterised a panel of sporadic colorectal adenocarcinomas for mutations in these three genes and has shown that p53 and K-ras mutations rarely occur in the same colorectal tumour. This suggests that mutations in these genes are on separate pathways to colorectal cancer development and may influence patient prognosis independently.

AB - Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal carcinogenesis. Our group has previously characterised a panel of sporadic colorectal adenocarcinomas for mutations in these three genes and has shown that p53 and K-ras mutations rarely occur in the same colorectal tumour. This suggests that mutations in these genes are on separate pathways to colorectal cancer development and may influence patient prognosis independently.

U2 - 10.1136/gut.2005.066514

DO - 10.1136/gut.2005.066514

M3 - Article

SN - 0017-5749

VL - 54

SP - 1283

EP - 1286

JO - Gut

JF - Gut

IS - 9

ER -