The promise and peril of chemical probes

Cheryl H. Arrowsmith; James E. Audia; Christopher Austin; Jonathan Baell; Jonathan Bennett; Julian Blagg; Chas Bountra; Paul E. Brennan; Peter J. Brown; Mark E. Bunnage; Carolyn Buser-Doepner; Robert M. Campbell; Adrian J. Carter; Philip Cohen; Robert A. Copeland; Ben Cravatt; Jayme L. Dahlin; Dashyant Dhanak; Aled M. Edwards; Mathias  Frederiksen; Stephen V. Frye; Nathanael Gray; Charles E. Grimshaw; David Hepworth; Trevor Howe; Kilian V. M. Huber; Jian Jin; Stefan Knapp; Joanne D. Kotz; Ryan G. Kruger; Derek Lowe; Mary M. Mader; Brian Marsden; Anke Mueller-Fahrnow; Susanne Müller; Ronan C. O'Hagan; John P. Overington; Dafydd R. Owen; Saul H. Rosenberg; Bryan Roth; Ruth Ross; Matthieu Schapira; Stuart L. Schreiber; Brian Shoichet; Michael Sundström; Giulio Superti-Furga; Jack Taunton; Leticia Toledo-Sherman; Chris Walpole; Michael A. Walters; Timothy M. Willson; Paul Workman; Robert N. Young; William J. Zuercher

doi:10.1038/nchembio.1867

The promise and peril of chemical probes

Cheryl H. Arrowsmith, James E. Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E. Brennan, Peter J. Brown, Mark E. Bunnage, Carolyn Buser-Doepner, Robert M. Campbell, Adrian J. Carter, Philip Cohen, Robert A. Copeland, Ben Cravatt, Jayme L. Dahlin, Dashyant Dhanak, Aled M. Edwards (Lead / Corresponding author), Mathias FrederiksenStephen V. Frye, Nathanael Gray, Charles E. Grimshaw, David Hepworth, Trevor Howe, Kilian V. M. Huber, Jian Jin, Stefan Knapp, Joanne D. Kotz, Ryan G. Kruger, Derek Lowe, Mary M. Mader, Brian Marsden, Anke Mueller-Fahrnow, Susanne Müller, Ronan C. O'Hagan, John P. Overington, Dafydd R. Owen, Saul H. Rosenberg, Bryan Roth, Ruth Ross, Matthieu Schapira, Stuart L. Schreiber, Brian Shoichet, Michael Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo-Sherman, Chris Walpole, Michael A. Walters, Timothy M. Willson, Paul Workman, Robert N. Young, William J. Zuercher

MRC PPU

Research output: Contribution to journal › Comment/debate › peer-review

643 Citations (Scopus)

Abstract

Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

Original language	English
Pages (from-to)	536-541
Number of pages	6
Journal	Nature Chemical Biology
Volume	11
Issue number	8
DOIs	https://doi.org/10.1038/nchembio.1867
Publication status	Published - Aug 2015

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., Buser-Doepner, C., Campbell, R. M., Carter, A. J., Cohen, P., Copeland, R. A., Cravatt, B., Dahlin, J. L., Dhanak, D., Edwards, A. M., ... Zuercher, W. J. (2015). The promise and peril of chemical probes. Nature Chemical Biology, 11(8), 536-541. https://doi.org/10.1038/nchembio.1867

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title = "The promise and peril of chemical probes",

abstract = "Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.",

author = "Arrowsmith, {Cheryl H.} and Audia, {James E.} and Christopher Austin and Jonathan Baell and Jonathan Bennett and Julian Blagg and Chas Bountra and Brennan, {Paul E.} and Brown, {Peter J.} and Bunnage, {Mark E.} and Carolyn Buser-Doepner and Campbell, {Robert M.} and Carter, {Adrian J.} and Philip Cohen and Copeland, {Robert A.} and Ben Cravatt and Dahlin, {Jayme L.} and Dashyant Dhanak and Edwards, {Aled M.} and Mathias Frederiksen and Frye, {Stephen V.} and Nathanael Gray and Grimshaw, {Charles E.} and David Hepworth and Trevor Howe and Huber, {Kilian V. M.} and Jian Jin and Stefan Knapp and Kotz, {Joanne D.} and Kruger, {Ryan G.} and Derek Lowe and Mader, {Mary M.} and Brian Marsden and Anke Mueller-Fahrnow and Susanne M{\"u}ller and O'Hagan, {Ronan C.} and Overington, {John P.} and Owen, {Dafydd R.} and Rosenberg, {Saul H.} and Bryan Roth and Ruth Ross and Matthieu Schapira and Schreiber, {Stuart L.} and Brian Shoichet and Michael Sundstr{\"o}m and Giulio Superti-Furga and Jack Taunton and Leticia Toledo-Sherman and Chris Walpole and Walters, {Michael A.} and Willson, {Timothy M.} and Paul Workman and Young, {Robert N.} and Zuercher, {William J.}",

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month = aug,

doi = "10.1038/nchembio.1867",

language = "English",

volume = "11",

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issn = "1552-4450",

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Arrowsmith, CH, Audia, JE, Austin, C, Baell, J, Bennett, J, Blagg, J, Bountra, C, Brennan, PE, Brown, PJ, Bunnage, ME, Buser-Doepner, C, Campbell, RM, Carter, AJ, Cohen, P, Copeland, RA, Cravatt, B, Dahlin, JL, Dhanak, D, Edwards, AM, Frederiksen, M, Frye, SV, Gray, N, Grimshaw, CE, Hepworth, D, Howe, T, Huber, KVM, Jin, J, Knapp, S, Kotz, JD, Kruger, RG, Lowe, D, Mader, MM, Marsden, B, Mueller-Fahrnow, A, Müller, S, O'Hagan, RC, Overington, JP, Owen, DR, Rosenberg, SH, Roth, B, Ross, R, Schapira, M, Schreiber, SL, Shoichet, B, Sundström, M, Superti-Furga, G, Taunton, J, Toledo-Sherman, L, Walpole, C, Walters, MA, Willson, TM, Workman, P, Young, RN & Zuercher, WJ 2015, 'The promise and peril of chemical probes', Nature Chemical Biology, vol. 11, no. 8, pp. 536-541. https://doi.org/10.1038/nchembio.1867

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T1 - The promise and peril of chemical probes

AU - Arrowsmith, Cheryl H.

AU - Audia, James E.

AU - Austin, Christopher

AU - Baell, Jonathan

AU - Bennett, Jonathan

AU - Blagg, Julian

AU - Bountra, Chas

AU - Brennan, Paul E.

AU - Brown, Peter J.

AU - Bunnage, Mark E.

AU - Buser-Doepner, Carolyn

AU - Campbell, Robert M.

AU - Carter, Adrian J.

AU - Cohen, Philip

AU - Copeland, Robert A.

AU - Cravatt, Ben

AU - Dahlin, Jayme L.

AU - Dhanak, Dashyant

AU - Edwards, Aled M.

AU - Frederiksen, Mathias

AU - Frye, Stephen V.

AU - Gray, Nathanael

AU - Grimshaw, Charles E.

AU - Hepworth, David

AU - Howe, Trevor

AU - Huber, Kilian V. M.

AU - Jin, Jian

AU - Knapp, Stefan

AU - Kotz, Joanne D.

AU - Kruger, Ryan G.

AU - Lowe, Derek

AU - Mader, Mary M.

AU - Marsden, Brian

AU - Mueller-Fahrnow, Anke

AU - Müller, Susanne

AU - O'Hagan, Ronan C.

AU - Overington, John P.

AU - Owen, Dafydd R.

AU - Rosenberg, Saul H.

AU - Roth, Bryan

AU - Ross, Ruth

AU - Schapira, Matthieu

AU - Schreiber, Stuart L.

AU - Shoichet, Brian

AU - Sundström, Michael

AU - Superti-Furga, Giulio

AU - Taunton, Jack

AU - Toledo-Sherman, Leticia

AU - Walpole, Chris

AU - Walters, Michael A.

AU - Willson, Timothy M.

AU - Workman, Paul

AU - Young, Robert N.

AU - Zuercher, William J.

PY - 2015/8

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N2 - Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

AB - Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

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U2 - 10.1038/nchembio.1867

DO - 10.1038/nchembio.1867

M3 - Comment/debate

C2 - 26196764

AN - SCOPUS:84937416706

SN - 1552-4450

VL - 11

SP - 536

EP - 541

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 8

ER -

The promise and peril of chemical probes

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Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)

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The promise and peril of chemical probes

Abstract

ASJC Scopus subject areas

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Projects

Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)

Cite this