The protection of 2′-hydroxy functions in oligoribonucleotide synthesis

David G. Norman, Colin B. Reese, Halina T. Serafinowska

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)


    The suitability of the 4-methoxytetrahydropyran-4-yl group for the protection of 2′ (or 3′)-hydroxy functions in oligoribonucleotide synthesis is confirmed; the latter protecting group is removed in 0.01M - hydrochloric acid at room temperature under conditions which, contrary to a recent report, lead to no detectable cleavage or migration of the internucleotide phosphodiester linkages.

    Original languageEnglish
    Pages (from-to)3015-3018
    Number of pages4
    JournalTetrahedron Letters
    Issue number28
    Publication statusPublished - 1984

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry


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