The protection of 2′-hydroxy functions in oligoribonucleotide synthesis

David G. Norman; Colin B. Reese; Halina T. Serafinowska

doi:10.1016/S0040-4039(01)81352-6

The protection of 2′-hydroxy functions in oligoribonucleotide synthesis

David G. Norman, Colin B. Reese, Halina T. Serafinowska

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26 Citations (Scopus)

Abstract

The suitability of the 4-methoxytetrahydropyran-4-yl group for the protection of 2′ (or 3′)-hydroxy functions in oligoribonucleotide synthesis is confirmed; the latter protecting group is removed in 0.01M - hydrochloric acid at room temperature under conditions which, contrary to a recent report, lead to no detectable cleavage or migration of the internucleotide phosphodiester linkages.

Original language	English
Pages (from-to)	3015-3018
Number of pages	4
Journal	Tetrahedron Letters
Volume	25
Issue number	28
DOIs	https://doi.org/10.1016/S0040-4039(01)81352-6
Publication status	Published - 1984

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)81352-6

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title = "The protection of 2′-hydroxy functions in oligoribonucleotide synthesis",

abstract = "The suitability of the 4-methoxytetrahydropyran-4-yl group for the protection of 2′ (or 3′)-hydroxy functions in oligoribonucleotide synthesis is confirmed; the latter protecting group is removed in 0.01M - hydrochloric acid at room temperature under conditions which, contrary to a recent report, lead to no detectable cleavage or migration of the internucleotide phosphodiester linkages.",

author = "Norman, {David G.} and Reese, {Colin B.} and Serafinowska, {Halina T.}",

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AU - Norman, David G.

AU - Reese, Colin B.

AU - Serafinowska, Halina T.

PY - 1984

Y1 - 1984

N2 - The suitability of the 4-methoxytetrahydropyran-4-yl group for the protection of 2′ (or 3′)-hydroxy functions in oligoribonucleotide synthesis is confirmed; the latter protecting group is removed in 0.01M - hydrochloric acid at room temperature under conditions which, contrary to a recent report, lead to no detectable cleavage or migration of the internucleotide phosphodiester linkages.

AB - The suitability of the 4-methoxytetrahydropyran-4-yl group for the protection of 2′ (or 3′)-hydroxy functions in oligoribonucleotide synthesis is confirmed; the latter protecting group is removed in 0.01M - hydrochloric acid at room temperature under conditions which, contrary to a recent report, lead to no detectable cleavage or migration of the internucleotide phosphodiester linkages.

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U2 - 10.1016/S0040-4039(01)81352-6

DO - 10.1016/S0040-4039(01)81352-6

M3 - Article

AN - SCOPUS:0004940265

SN - 0040-4039

VL - 25

SP - 3015

EP - 3018

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

The protection of 2′-hydroxy functions in oligoribonucleotide synthesis

Abstract

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