The real LAT steps forward

TY - JOUR

T1 - The real LAT steps forward

AU - Cantrell, Doreen

PY - 1998/5/1

Y1 - 1998/5/1

N2 - Antigen receptors initiate T-cell activation and determine the specificity of the immune response by activating membrane-localized protein tyrosine kinases. Signalling pathways initiated by these kinases control expression of the genes that mediate T-cell effector function. A major challenge in immunology is to work out the route taken by membrane-generated signals as they transit to the nucleus. Substrates for the ZAP70/Syk tyrosine kinases are important, but 'missing', links in this process. There has finally been some progress in characterizing one of these important linkers: LAT, an integral membrane protein that acts as an adaptor to couple antigen receptors to intracellular signalling cascades.

AB - Antigen receptors initiate T-cell activation and determine the specificity of the immune response by activating membrane-localized protein tyrosine kinases. Signalling pathways initiated by these kinases control expression of the genes that mediate T-cell effector function. A major challenge in immunology is to work out the route taken by membrane-generated signals as they transit to the nucleus. Substrates for the ZAP70/Syk tyrosine kinases are important, but 'missing', links in this process. There has finally been some progress in characterizing one of these important linkers: LAT, an integral membrane protein that acts as an adaptor to couple antigen receptors to intracellular signalling cascades.

UR - https://www.scopus.com/pages/publications/0032080391

U2 - 10.1016/S0962-8924(98)01264-1

DO - 10.1016/S0962-8924(98)01264-1

M3 - Article

C2 - 9695835

AN - SCOPUS:0032080391

SN - 0962-8924

VL - 8

SP - 180

EP - 182

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 5

ER -