TY - CHAP
T1 - The regulation and function of p21ras in signal transduction by the T cell antigen receptor
AU - Cantrell, Doreen
AU - Pastor, M. Izquierdo
AU - Woodrow, M.
PY - 1994/1
Y1 - 1994/1
N2 - T lymphocyte activation is initiated by triggering of the T cell antigen receptor (TCR). The TCR is a multichain complex comprising a disulfide-linked heterodimer of the idiotypic αβ chains noncovalently associated with a signal transduction complex composed of the invariant CD3 γ, δ, ϵ chains and the ζ (16 kDa) and η (22 kDa) subunits.1–3 The cytoplasmic domains of the CD3 and ζ subunits are crucial for TCR coupling to intracellular PTKs which is absolutely required for all subsequent T cell responses.4–8 PTKs are known to couple the TCR to an inositol lipid specific phospholipase C, PLCγ19 thus enabling the TCR to regulate the hydrolysis of membrane phosphoinositides (PtdIns), in particular phosphatidylinositol (4,5)-biphosphate (PtdIns(4,5P2), liberating inositol (1,4,5)-triphosphate(Ins(1,4,5)P3) and 1,2-diacylglycerol (DAG). Ins(1,4,5)P3 releases Ca2+ from the endoplasmic reticulum which results in an initial rapid rise in the concentration of intracellular Ca2+; DAG is known to activate the serine/threonin kinase, protein kinase C (PKC).10–12
AB - T lymphocyte activation is initiated by triggering of the T cell antigen receptor (TCR). The TCR is a multichain complex comprising a disulfide-linked heterodimer of the idiotypic αβ chains noncovalently associated with a signal transduction complex composed of the invariant CD3 γ, δ, ϵ chains and the ζ (16 kDa) and η (22 kDa) subunits.1–3 The cytoplasmic domains of the CD3 and ζ subunits are crucial for TCR coupling to intracellular PTKs which is absolutely required for all subsequent T cell responses.4–8 PTKs are known to couple the TCR to an inositol lipid specific phospholipase C, PLCγ19 thus enabling the TCR to regulate the hydrolysis of membrane phosphoinositides (PtdIns), in particular phosphatidylinositol (4,5)-biphosphate (PtdIns(4,5P2), liberating inositol (1,4,5)-triphosphate(Ins(1,4,5)P3) and 1,2-diacylglycerol (DAG). Ins(1,4,5)P3 releases Ca2+ from the endoplasmic reticulum which results in an initial rapid rise in the concentration of intracellular Ca2+; DAG is known to activate the serine/threonin kinase, protein kinase C (PKC).10–12
KW - Tyrosine Phosphorylation
KW - Guanine Nucleotide
KW - Cell Antigen Receptor
KW - Imperial Cancer Research Fund
KW - Initial Rapid Rise
UR - http://www.scopus.com/inward/record.url?scp=0028051549&partnerID=8YFLogxK
U2 - 10.1007/978-1-4899-0987-9_8
DO - 10.1007/978-1-4899-0987-9_8
M3 - Chapter
C2 - 7887315
AN - SCOPUS:0028051549
SN - 9781489909893
VL - 365
T3 - Advances in Experimental Medicine and Biology
SP - 73
EP - 79
BT - Mechanisms of lymphocyte activation and immune regulation V
A2 - Gupta, Sudhir
A2 - Paul, William E.
A2 - DeFranco, Anthony
A2 - Perlmutter, Roger M.
PB - Springer
CY - New York
ER -
