The regulation and function of p21ras in signal transduction by the T cell antigen receptor

Doreen Cantrell, M. Izquierdo Pastor, M. Woodrow

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

T lymphocyte activation is initiated by triggering of the T cell antigen receptor (TCR). The TCR is a multichain complex comprising a disulfide-linked heterodimer of the idiotypic αβ chains noncovalently associated with a signal transduction complex composed of the invariant CD3 γ, δ, ϵ chains and the ζ (16 kDa) and η (22 kDa) subunits.1–3 The cytoplasmic domains of the CD3 and ζ subunits are crucial for TCR coupling to intracellular PTKs which is absolutely required for all subsequent T cell responses.4–8 PTKs are known to couple the TCR to an inositol lipid specific phospholipase C, PLCγ19 thus enabling the TCR to regulate the hydrolysis of membrane phosphoinositides (PtdIns), in particular phosphatidylinositol (4,5)-biphosphate (PtdIns(4,5P2), liberating inositol (1,4,5)-triphosphate(Ins(1,4,5)P3) and 1,2-diacylglycerol (DAG). Ins(1,4,5)P3 releases Ca2+ from the endoplasmic reticulum which results in an initial rapid rise in the concentration of intracellular Ca2+; DAG is known to activate the serine/threonin kinase, protein kinase C (PKC).10–12
Original languageEnglish
Title of host publicationMechanisms of lymphocyte activation and immune regulation V
Subtitle of host publicationMolecular basis of signal transduction
EditorsSudhir Gupta, William E. Paul, Anthony DeFranco, Roger M. Perlmutter
Place of PublicationNew York
PublisherSpringer
Pages73-79
Number of pages7
Volume365
ISBN (Electronic) 9781489909879
ISBN (Print) 9781489909893
DOIs
Publication statusPublished - Jan 1994

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer New York
ISSN (Print)0065-2598

Keywords

  • Tyrosine Phosphorylation
  • Guanine Nucleotide
  • Cell Antigen Receptor
  • Imperial Cancer Research Fund
  • Initial Rapid Rise

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