The regulation of lymphocyte activation and proliferation

Susanne Heinzel (Lead / Corresponding author), Julia M. Marchingo, Miles B. Horton, Philip D. Hodgkin

Research output: Contribution to journalReview article

12 Citations (Scopus)
70 Downloads (Pure)

Abstract

Activation induced proliferation and clonal expansion of antigen specific lymphocytes is a hallmark of the adaptive immune response to pathogens. Recent studies identify two distinct control phases. In the first T and B lymphocytes integrate antigen and additional costimuli to motivate a programmed proliferative burst that ceases with a return to cell quiescence and eventual death. This proliferative burst is autonomously timed, ensuring an appropriate response magnitude whilst preventing uncontrolled expansion. This initial response is subject to further modification and extension by a range of signals that modify, expand and direct the emergence of a rich array of new cell types. Thus, both robust clonal expansion of a small number of antigen specific T cells, and the concurrent emergence of extensive cellular diversity, confers immunity to a vast array of different pathogens. The in vivo response to a given pathogen is made up by the sum of all responding clones and is reproducible and pathogen specific. Thus, a precise description of the regulatory principles governing lymphocyte proliferation, differentiation and survival is essential to a unified understanding of the immune system.

Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalCurrent Opinion in Immunology
Volume51
Early online date3 Feb 2018
DOIs
Publication statusPublished - Apr 2018

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Lymphocyte Activation
Antigens
Lymphocytes
T-Lymphocytes
Adaptive Immunity
Immune System
Immunity
B-Lymphocytes
Clone Cells

Cite this

Heinzel, Susanne ; Marchingo, Julia M. ; Horton, Miles B. ; Hodgkin, Philip D. / The regulation of lymphocyte activation and proliferation. In: Current Opinion in Immunology. 2018 ; Vol. 51. pp. 32-38.
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The regulation of lymphocyte activation and proliferation. / Heinzel, Susanne (Lead / Corresponding author); Marchingo, Julia M.; Horton, Miles B.; Hodgkin, Philip D.

In: Current Opinion in Immunology, Vol. 51, 04.2018, p. 32-38.

Research output: Contribution to journalReview article

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AU - Heinzel, Susanne

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AU - Horton, Miles B.

AU - Hodgkin, Philip D.

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PY - 2018/4

Y1 - 2018/4

N2 - Activation induced proliferation and clonal expansion of antigen specific lymphocytes is a hallmark of the adaptive immune response to pathogens. Recent studies identify two distinct control phases. In the first T and B lymphocytes integrate antigen and additional costimuli to motivate a programmed proliferative burst that ceases with a return to cell quiescence and eventual death. This proliferative burst is autonomously timed, ensuring an appropriate response magnitude whilst preventing uncontrolled expansion. This initial response is subject to further modification and extension by a range of signals that modify, expand and direct the emergence of a rich array of new cell types. Thus, both robust clonal expansion of a small number of antigen specific T cells, and the concurrent emergence of extensive cellular diversity, confers immunity to a vast array of different pathogens. The in vivo response to a given pathogen is made up by the sum of all responding clones and is reproducible and pathogen specific. Thus, a precise description of the regulatory principles governing lymphocyte proliferation, differentiation and survival is essential to a unified understanding of the immune system.

AB - Activation induced proliferation and clonal expansion of antigen specific lymphocytes is a hallmark of the adaptive immune response to pathogens. Recent studies identify two distinct control phases. In the first T and B lymphocytes integrate antigen and additional costimuli to motivate a programmed proliferative burst that ceases with a return to cell quiescence and eventual death. This proliferative burst is autonomously timed, ensuring an appropriate response magnitude whilst preventing uncontrolled expansion. This initial response is subject to further modification and extension by a range of signals that modify, expand and direct the emergence of a rich array of new cell types. Thus, both robust clonal expansion of a small number of antigen specific T cells, and the concurrent emergence of extensive cellular diversity, confers immunity to a vast array of different pathogens. The in vivo response to a given pathogen is made up by the sum of all responding clones and is reproducible and pathogen specific. Thus, a precise description of the regulatory principles governing lymphocyte proliferation, differentiation and survival is essential to a unified understanding of the immune system.

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