The regulation of MDM2 by multisite phosphorylation-Opportunities for molecular-based intervention to target tumours?

Keyphrases

• Tumor 100%
• Multisite Phosphorylation 100%
• Murine Double Minute 2 (MDM2) 100%
• Gene Expression 25%
• Signaling Pathway 12%
• Tumor Cells 12%
• Apoptosis 12%
• Protein-protein Interaction 12%
• Interacting Proteins 12%
• Tumor Protein p53 (TP53) 12%
• Cellular Stress 12%
• Transcription Factor 12%
• Transactivation 12%
• Post-translational Modification 12%
• E3 Ubiquitin Ligase 12%
• Proteasomal Degradation 12%
• Negative Regulator 12%
• Growth Arrest 12%
• Signaling Mechanism 12%
• Negative Feedback Loop 12%
• Ubiquitylation 12%
• P53 Transactivation 12%
• P53 Response 12%
• Non-genotoxic 12%
• Physiological Level 12%
• Coordinated Regulation 12%
• Senescence 12%
• Peptide Docking 12%
• MDM2 Gene 12%
• Protein Turnover 12%
• Phosphorylation Reaction 12%
• Regulatory Event 12%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Gene Expression 20%
• Transcription Factors 10%
• Transactivation 10%
• Tumor Suppressor Protein 10%
• Cell Stress 10%
• Protein-Protein Interaction 10%
• Ubiquitination 10%
• Proteasome 10%
• Posttranslational Modification 10%
• Ubiquitin-Conjugating Enzyme 10%
• Signaling Mechanism 10%
• Protein Degradation 10%
• Programmed Cell Death 10%