The regulation of protein function by multisite phosphorylation - A 25 year update

Philip Cohen

doi:10.1016/S0968-0004(00)01712-6

The regulation of protein function by multisite phosphorylation - A 25 year update

Philip Cohen

Research output: Contribution to journal › Review article › peer-review

957 Citations (Scopus)

Abstract

The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. 'Multisite phosphorylation can enable several such effects to operate in the same protein. It can also determine the extent and duration of a response and is the key to signal integration.

Original language	English
Pages (from-to)	596-601
Number of pages	6
Journal	Trends in Biochemical Sciences
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/S0968-0004(00)01712-6
Publication status	Published - 1 Dec 2000

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/S0968-0004(00)01712-6Licence: Elsevier User Licence

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AB - The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. 'Multisite phosphorylation can enable several such effects to operate in the same protein. It can also determine the extent and duration of a response and is the key to signal integration.

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The regulation of protein function by multisite phosphorylation - A 25 year update

Abstract

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