The regulation of protein function by multisite phosphorylation - A 25 year update

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    817 Citations (Scopus)

    Abstract

    The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. 'Multisite phosphorylation can enable several such effects to operate in the same protein. It can also determine the extent and duration of a response and is the key to signal integration.

    Original languageEnglish
    Pages (from-to)596-601
    Number of pages6
    JournalTrends in Biochemical Sciences
    Volume25
    Issue number12
    DOIs
    Publication statusPublished - 1 Dec 2000

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