The regulation of replication origin activation

Anne D. Donaldson, J. Julian Blow

    Research output: Contribution to journalArticlepeer-review

    78 Citations (Scopus)


    At the start of the cell-division programme, proteins must be assembled onto replication origins to establish competence for initiation of DNA synthesis. At the correct moment, other effectors must then coordinate appropriate firing of the various origins to control entry into and progress through S phase. These processes are key targets of cell-cycle control, and understanding their regulation will provide a deeper knowledge of the mechanisms controlling cell proliferation.
    Original languageEnglish
    Pages (from-to)62-68
    Number of pages7
    JournalCurrent Opinion in Genetics & Development
    Issue number1
    Publication statusPublished - 1999


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