The regulation of replication origin activation

TY - JOUR

T1 - The regulation of replication origin activation

AU - Donaldson, Anne D.

AU - Blow, J. Julian

PY - 1999

Y1 - 1999

N2 - At the start of the cell-division programme, proteins must be assembled onto replication origins to establish competence for initiation of DNA synthesis. At the correct moment, other effectors must then coordinate appropriate firing of the various origins to control entry into and progress through S phase. These processes are key targets of cell-cycle control, and understanding their regulation will provide a deeper knowledge of the mechanisms controlling cell proliferation.

AB - At the start of the cell-division programme, proteins must be assembled onto replication origins to establish competence for initiation of DNA synthesis. At the correct moment, other effectors must then coordinate appropriate firing of the various origins to control entry into and progress through S phase. These processes are key targets of cell-cycle control, and understanding their regulation will provide a deeper knowledge of the mechanisms controlling cell proliferation.

U2 - 10.1016/S0959-437X(99)80009-4

DO - 10.1016/S0959-437X(99)80009-4

M3 - Article

C2 - 10072361

SN - 0959-437X

VL - 9

SP - 62

EP - 68

JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

IS - 1

ER -