TY - JOUR
T1 - The regulation of T-cell proliferation
T2 - a role for protein kinase C.
AU - Cantrell, D. A.
AU - Davies, A. A.
AU - Verbi, W.
AU - Crumpton, M. J.
PY - 1987
Y1 - 1987
N2 - T-lymphocyte proliferation is regulated by the T-cell growth factor interleukin 2 (IL-2) which exerts its biological effects through an interaction with high-affinity specific IL-2 receptors [1–3]. Quiescent T-lymphocytes neither produce IL-2 nor express IL-2 receptors [2, 4]. However, following immune stimulation there is transcriptional activation of both the IL-2 and IL-2 receptor genes which results in IL-2 synthesis and IL-2 receptor expression [5–7]. T-cell proliferation can then proceed via an autocrine pathway in which the population secretes and responds to its own growth factor
AB - T-lymphocyte proliferation is regulated by the T-cell growth factor interleukin 2 (IL-2) which exerts its biological effects through an interaction with high-affinity specific IL-2 receptors [1–3]. Quiescent T-lymphocytes neither produce IL-2 nor express IL-2 receptors [2, 4]. However, following immune stimulation there is transcriptional activation of both the IL-2 and IL-2 receptor genes which results in IL-2 synthesis and IL-2 receptor expression [5–7]. T-cell proliferation can then proceed via an autocrine pathway in which the population secretes and responds to its own growth factor
UR - http://www.scopus.com/inward/record.url?scp=0023517485&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-72624-8_71
DO - 10.1007/978-3-642-72624-8_71
M3 - Article
C2 - 3127283
AN - SCOPUS:0023517485
SN - 0171-7111
VL - 31
SP - 341
EP - 346
JO - Haematology and blood transfusion
JF - Haematology and blood transfusion
ER -