The relationship between blood viscosity and blood pressure in a random sample of the population aged 55 to 74 years

F. G.R. Fowkes (Lead / Corresponding author), G. D.O. Lowe, A. Rumley, S. E. Lennie, F. B. Smith, P. T. Donnan

Research output: Contribution to journalArticle

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Abstract

Blood viscosity is elevated in hypertensive subjects, but the association of viscosity with arterial blood pressure in the general population, and the influence of social, lifestyle and disease characteristics on this association, are not established. In the Edinburgh Artery Study, 1592 men and women aged 55-74 years selected randomly from the general population attended a university clinic. A fasting blood sample was taken for the measurement of blood viscosity and its major determinants (haematocrit, plasma viscosity and fibrinogen). Systolic pressure was related univariately to blood viscosity (P < 0.001), plasma viscosity (P < 0.001) and plasma fibrinogen (P < 0.01), but the association with fibrinogen did not persist after adjusting for body mass index. Diastolic pressure was related univariately to blood viscosity (P < 0.001) and plasma viscosity (P < 0.001) and haematocrit (P < 0.001) but not to fibrinogen. The only difference between the sexes was that the association between blood viscosity and systolic pressure was confined to males. Blood viscosity was associated equally with systolic and diastolic pressures in males, and remained independently related on multivariate analysis adjusting for age, sex, body mass index, social class, smoking, alcohol intake, exercise, angina, HDL and non-HDL cholesterol, diabetes mellitus, plasma viscosity, fibrinogen, and haematocrit.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalEuropean Heart Journal
Volume14
Issue number5
DOIs
Publication statusPublished - 1 Jan 1993

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Blood Viscosity
Viscosity
Fibrinogen
Blood Pressure
Hematocrit
Population
Body Mass Index
Social Class
Sex Characteristics
Life Style
Fasting
Diabetes Mellitus
Arterial Pressure
Multivariate Analysis
Arteries
Smoking
Cholesterol
Alcohols
Exercise

Keywords

  • Blood pressure
  • Blood viscosity
  • Cross sectional survey
  • Fibrinogen

Cite this

Fowkes, F. G.R. ; Lowe, G. D.O. ; Rumley, A. ; Lennie, S. E. ; Smith, F. B. ; Donnan, P. T. / The relationship between blood viscosity and blood pressure in a random sample of the population aged 55 to 74 years. In: European Heart Journal. 1993 ; Vol. 14, No. 5. pp. 597-601.
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The relationship between blood viscosity and blood pressure in a random sample of the population aged 55 to 74 years. / Fowkes, F. G.R. (Lead / Corresponding author); Lowe, G. D.O.; Rumley, A.; Lennie, S. E.; Smith, F. B.; Donnan, P. T.

In: European Heart Journal, Vol. 14, No. 5, 01.01.1993, p. 597-601.

Research output: Contribution to journalArticle

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