The RhoA transcriptional program in pre-T cells

M. Mullin, K. Lightfoot, R. Clarke, D. Cantrell, M. Miller, R. Lahesmaa

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    Abstract

    The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors. The data show that RhoA plays a specific and essential role in pre-T cells because it is required for the expression of transcription factors of the Egr-1 and AP-1 families that have critical functions in thymocyte development. Loss of RhoA function in T cell progenitors causes a developmental block that pheno-copies the consequence of losing pre-TCR expression in Recombinase gene 2 (Rag2) null mice. Transcriptional profiling reveals both common and unique gene targets for RhoA and the pre-TCR indicating that RhoA participates in the pre-TCR induced transcriptional program but also mediates pre-TCR independent gene transcription.
    Original languageEnglish
    Pages (from-to)4309-4317
    Number of pages9
    JournalFEBS Letters
    Volume581
    Issue number22
    DOIs
    Publication statusPublished - 4 Sep 2007

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