The RhoA transcriptional program in pre-T cells

M. Mullin; K. Lightfoot; R. Clarke; D. Cantrell; M. Miller; R. Lahesmaa

doi:10.1016/j.febslet.2007.07.077

The RhoA transcriptional program in pre-T cells

M. Mullin, K. Lightfoot, R. Clarke, D. Cantrell, M. Miller, R. Lahesmaa

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Abstract

The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors. The data show that RhoA plays a specific and essential role in pre-T cells because it is required for the expression of transcription factors of the Egr-1 and AP-1 families that have critical functions in thymocyte development. Loss of RhoA function in T cell progenitors causes a developmental block that pheno-copies the consequence of losing pre-TCR expression in Recombinase gene 2 (Rag2) null mice. Transcriptional profiling reveals both common and unique gene targets for RhoA and the pre-TCR indicating that RhoA participates in the pre-TCR induced transcriptional program but also mediates pre-TCR independent gene transcription.

Original language	English
Pages (from-to)	4309-4317
Number of pages	9
Journal	FEBS Letters
Volume	581
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2007.07.077
Publication status	Published - 4 Sept 2007

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http://ukpmc.ac.uk/articles/PMC1964784

Cite this

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title = "The RhoA transcriptional program in pre-T cells",

abstract = "The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors. The data show that RhoA plays a specific and essential role in pre-T cells because it is required for the expression of transcription factors of the Egr-1 and AP-1 families that have critical functions in thymocyte development. Loss of RhoA function in T cell progenitors causes a developmental block that pheno-copies the consequence of losing pre-TCR expression in Recombinase gene 2 (Rag2) null mice. Transcriptional profiling reveals both common and unique gene targets for RhoA and the pre-TCR indicating that RhoA participates in the pre-TCR induced transcriptional program but also mediates pre-TCR independent gene transcription.",

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AU - Lightfoot, K.

AU - Clarke, R.

AU - Cantrell, D.

AU - Miller, M.

AU - Lahesmaa, R.

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AB - The GTPase RhoA is essential for the development of pre-T cells in the thymus. To investigate the mechanisms used by RhoA to control thymocyte development we have used Affymetrix gene profiling to identify RhoA regulated genes in T cell progenitors. The data show that RhoA plays a specific and essential role in pre-T cells because it is required for the expression of transcription factors of the Egr-1 and AP-1 families that have critical functions in thymocyte development. Loss of RhoA function in T cell progenitors causes a developmental block that pheno-copies the consequence of losing pre-TCR expression in Recombinase gene 2 (Rag2) null mice. Transcriptional profiling reveals both common and unique gene targets for RhoA and the pre-TCR indicating that RhoA participates in the pre-TCR induced transcriptional program but also mediates pre-TCR independent gene transcription.

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The RhoA transcriptional program in pre-T cells

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