The RNA polymerase I transcription machinery

Jackie Russell, Joost C. B. M. Zomerdijk

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    134 Citations (Scopus)


    The rRNAs constitute the catalytic and structural components of the ribosome, the protein synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA polymerise I), therefore has a major impact on the life and destiny of a cell. In order to elucidate how cells achieve the stringent control of Pol I transcription, matching the supply of rRNA to demand under different cellular growth conditions, it is essential to understand the components and mechanics of the Pol I transcription machinery. In this review, we discuss: (1) the molecular composition and functions of the Pol I enzyme complex and the two main Pol I transcription factors, SL1 (selectivity factor 1) and UBF (upstream binding factor); (ii) the interplay between these factors during pre-initiation complex formation at the rDNA promoter in mammalian cells; and (iii) the cellular control of the Pol I transcription machinery.

    Original languageEnglish
    Title of host publicationTranscription
    Subtitle of host publicationpapers from the Biochemical Society symposium no. 73, held at Imperial College, London, April 2005
    EditorsS. Roberts, R. Weinzierl, R. White
    Place of PublicationLondon
    PublisherPortland Press
    Number of pages14
    ISBN (Print)1855781638
    Publication statusPublished - 2006
    EventBiochemical Society Annual Symposium ‘Transcription UK 2005’ - London, United Kingdom
    Duration: 13 Apr 200515 Apr 2005

    Publication series

    NameBiochemical Society symposia
    ISSN (Print)0067-8964


    ConferenceBiochemical Society Annual Symposium ‘Transcription UK 2005’
    Country/TerritoryUnited Kingdom
    Internet address


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