Research output per year
Research output per year
Jackie Russell, Joost C. B. M. Zomerdijk
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
The rRNAs constitute the catalytic and structural components of the ribosome, the protein synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA polymerise I), therefore has a major impact on the life and destiny of a cell. In order to elucidate how cells achieve the stringent control of Pol I transcription, matching the supply of rRNA to demand under different cellular growth conditions, it is essential to understand the components and mechanics of the Pol I transcription machinery. In this review, we discuss: (1) the molecular composition and functions of the Pol I enzyme complex and the two main Pol I transcription factors, SL1 (selectivity factor 1) and UBF (upstream binding factor); (ii) the interplay between these factors during pre-initiation complex formation at the rDNA promoter in mammalian cells; and (iii) the cellular control of the Pol I transcription machinery.
Original language | English |
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Title of host publication | Transcription |
Subtitle of host publication | papers from the Biochemical Society symposium no. 73, held at Imperial College, London, April 2005 |
Editors | S. Roberts, R. Weinzierl, R. White |
Place of Publication | London |
Publisher | Portland Press |
Pages | 203-216 |
Number of pages | 14 |
ISBN (Print) | 1855781638 |
Publication status | Published - 2006 |
Event | Biochemical Society Annual Symposium ‘Transcription UK 2005’ - London, United Kingdom Duration: 13 Apr 2005 → 15 Apr 2005 http://www.biochemistry.org/Conferences/AllConferences/tabid/379/View/GeneralInfo/Filter/64%2012AS/MeetingNo/SA035/Default.aspx |
Name | Biochemical Society symposia |
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Volume | 73 |
ISSN (Print) | 0067-8964 |
Conference | Biochemical Society Annual Symposium ‘Transcription UK 2005’ |
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Country/Territory | United Kingdom |
City | London |
Period | 13/04/05 → 15/04/05 |
Internet address |
Research output: Contribution to conference › Paper
Russell, J. (Participant)
Activity: Participating in or organising an event types › Participation in conference
Zomerdijk, J. (Participant)
Activity: Participating in or organising an event types › Participation in conference