Aldosterone has a variety of detrimental effects on the heart and vasculature and is increasingly recognized as an important target in chronic heart failure, as illustrated by the Randomized Aldactone Evaluation Study. In this article, the evidence supporting the cardiovascular effects of aldosterone in humans and the proven benefits of aldosterone-receptor antagonists in heart failure shall be discussed.
Dawson, A., Davies, J. I., & Struthers, A. D. (2004). The role of aldosterone in heart failure and the clinical benefits of aldosterone blockade. Expert Review of Cardiovascular Therapy, 2(1), 29-36. https://doi.org/10.1586/14779072.2.1.29