The role of Ca2+ in ultrasound-elicited bioeffects: progress, perspectives and prospects

Mariame A. Hassan, Paul Campbell, Takashi Kondo

    Research output: Contribution to journalReview articlepeer-review

    68 Citations (Scopus)

    Abstract

    Intracellular calcium (Ca2+) transients have been observed in association with exposure to therapeutic ultrasound and correlated to both early- and late-onset bioeffects. For example, it has been suggested that early 'ultra-short' Ca2+ transients recorded during sonoporation can mediate Ca2+-dependent exocytosis and endocytosis processes as complementary mechanisms for membrane self-sealing. Moreover, apoptosis induction has been reported to occur through a partial mediation of a Ca2+-dependent pathway. In this review, we attempt to assemble the salient facts into a cogent whole, with special attention given to the relationships arising through altered Ca2+ levels, which underscore its crucial role during ultrasonic interactions with biological systems and its consequent implications in the context of therapeutics.

    Original languageEnglish
    Pages (from-to)892-906
    Number of pages15
    JournalDrug Discovery Today
    Volume15
    Issue number21-22
    DOIs
    Publication statusPublished - Nov 2010

    Keywords

    • INTENSITY PULSED ULTRASOUND
    • PLASMA-MEMBRANE REPAIR
    • HUMAN LEUKEMIA-CELLS
    • HAMSTER OVARY CELLS
    • ECHO-CONTRAST AGENT
    • IN-VITRO
    • THERAPEUTIC ULTRASOUND
    • INDUCED APOPTOSIS
    • DNA-DAMAGE
    • ENDOPLASMIC-RETICULUM

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