The role of Ca2+ in ultrasound-elicited bioeffects: progress, perspectives and prospects

Mariame A. Hassan; Paul Campbell; Takashi Kondo

doi:10.1016/j.drudis.2010.08.005

The role of Ca2+ in ultrasound-elicited bioeffects: progress, perspectives and prospects

Mariame A. Hassan
, Paul Campbell
, Takashi Kondo

Research output: Contribution to journal › Review article › peer-review

94 Citations (Scopus)

Abstract

Intracellular calcium (Ca2+) transients have been observed in association with exposure to therapeutic ultrasound and correlated to both early- and late-onset bioeffects. For example, it has been suggested that early 'ultra-short' Ca2+ transients recorded during sonoporation can mediate Ca2+-dependent exocytosis and endocytosis processes as complementary mechanisms for membrane self-sealing. Moreover, apoptosis induction has been reported to occur through a partial mediation of a Ca2+-dependent pathway. In this review, we attempt to assemble the salient facts into a cogent whole, with special attention given to the relationships arising through altered Ca2+ levels, which underscore its crucial role during ultrasonic interactions with biological systems and its consequent implications in the context of therapeutics.

Original language	English
Pages (from-to)	892-906
Number of pages	15
Journal	Drug Discovery Today
Volume	15
Issue number	21-22
DOIs	https://doi.org/10.1016/j.drudis.2010.08.005
Publication status	Published - Nov 2010

Keywords

INTENSITY PULSED ULTRASOUND
PLASMA-MEMBRANE REPAIR
HUMAN LEUKEMIA-CELLS
HAMSTER OVARY CELLS
ECHO-CONTRAST AGENT
IN-VITRO
THERAPEUTIC ULTRASOUND
INDUCED APOPTOSIS
DNA-DAMAGE
ENDOPLASMIC-RETICULUM

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10.1016/j.drudis.2010.08.005

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title = "The role of Ca2+ in ultrasound-elicited bioeffects: progress, perspectives and prospects",

abstract = "Intracellular calcium (Ca2+) transients have been observed in association with exposure to therapeutic ultrasound and correlated to both early- and late-onset bioeffects. For example, it has been suggested that early 'ultra-short' Ca2+ transients recorded during sonoporation can mediate Ca2+-dependent exocytosis and endocytosis processes as complementary mechanisms for membrane self-sealing. Moreover, apoptosis induction has been reported to occur through a partial mediation of a Ca2+-dependent pathway. In this review, we attempt to assemble the salient facts into a cogent whole, with special attention given to the relationships arising through altered Ca2+ levels, which underscore its crucial role during ultrasonic interactions with biological systems and its consequent implications in the context of therapeutics.",

keywords = "INTENSITY PULSED ULTRASOUND, PLASMA-MEMBRANE REPAIR, HUMAN LEUKEMIA-CELLS, HAMSTER OVARY CELLS, ECHO-CONTRAST AGENT, IN-VITRO, THERAPEUTIC ULTRASOUND, INDUCED APOPTOSIS, DNA-DAMAGE, ENDOPLASMIC-RETICULUM",

author = "Hassan, \{Mariame A.\} and Paul Campbell and Takashi Kondo",

year = "2010",

month = nov,

doi = "10.1016/j.drudis.2010.08.005",

language = "English",

volume = "15",

pages = "892--906",

journal = "Drug Discovery Today",

issn = "1359-6446",

publisher = "Elsevier",

number = "21-22",

}

TY - JOUR

T1 - The role of Ca2+ in ultrasound-elicited bioeffects

T2 - progress, perspectives and prospects

AU - Hassan, Mariame A.

AU - Campbell, Paul

AU - Kondo, Takashi

PY - 2010/11

Y1 - 2010/11

N2 - Intracellular calcium (Ca2+) transients have been observed in association with exposure to therapeutic ultrasound and correlated to both early- and late-onset bioeffects. For example, it has been suggested that early 'ultra-short' Ca2+ transients recorded during sonoporation can mediate Ca2+-dependent exocytosis and endocytosis processes as complementary mechanisms for membrane self-sealing. Moreover, apoptosis induction has been reported to occur through a partial mediation of a Ca2+-dependent pathway. In this review, we attempt to assemble the salient facts into a cogent whole, with special attention given to the relationships arising through altered Ca2+ levels, which underscore its crucial role during ultrasonic interactions with biological systems and its consequent implications in the context of therapeutics.

AB - Intracellular calcium (Ca2+) transients have been observed in association with exposure to therapeutic ultrasound and correlated to both early- and late-onset bioeffects. For example, it has been suggested that early 'ultra-short' Ca2+ transients recorded during sonoporation can mediate Ca2+-dependent exocytosis and endocytosis processes as complementary mechanisms for membrane self-sealing. Moreover, apoptosis induction has been reported to occur through a partial mediation of a Ca2+-dependent pathway. In this review, we attempt to assemble the salient facts into a cogent whole, with special attention given to the relationships arising through altered Ca2+ levels, which underscore its crucial role during ultrasonic interactions with biological systems and its consequent implications in the context of therapeutics.

KW - INTENSITY PULSED ULTRASOUND

KW - PLASMA-MEMBRANE REPAIR

KW - HUMAN LEUKEMIA-CELLS

KW - HAMSTER OVARY CELLS

KW - ECHO-CONTRAST AGENT

KW - IN-VITRO

KW - THERAPEUTIC ULTRASOUND

KW - INDUCED APOPTOSIS

KW - DNA-DAMAGE

KW - ENDOPLASMIC-RETICULUM

U2 - 10.1016/j.drudis.2010.08.005

DO - 10.1016/j.drudis.2010.08.005

M3 - Review article

C2 - 20727981

SN - 1359-6446

VL - 15

SP - 892

EP - 906

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 21-22

ER -

The role of Ca2+ in ultrasound-elicited bioeffects: progress, perspectives and prospects

Abstract

Keywords

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