The role of cardiac biochemical markers in aortic stenosis

Calvin W. L. Chin (Lead / Corresponding author), Andie H. Djohan, Chim C. Lang

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Calcified aortic stenosis is one of the most common causes of heart failure in the elderly. Current guidelines recommend aortic valve replacement in patients with severe disease and evidence of decompensation based on either symptoms or impaired systolic ejection fraction. However, symptoms are often subjective whilst impaired ejection fraction is not a sensitive marker of ventricular decompensation. Interest has surrounded the use of cardiac biochemical markers as objective measures of left ventricular decompensation in aortic stenosis. We will first examine mechanisms of release of biochemical markers associated with myocardial wall stress (BNP/NT-proBNP), myocardial fibrosis (markers of collagen metabolism, galectin-3, soluble ST2) and myocyte death/myocardial ischemia (high-sensitivity cardiac troponins, heart-type fatty acid binding protein, myosin-binding protein C); and discuss future directions of these markers.

Original languageEnglish
Pages (from-to)316-327
Number of pages12
Issue number4
Early online date22 Feb 2016
Publication statusPublished - 2016


  • Aortic stenosis
  • cardiac biochemical markers
  • left ventricular hypertrophy
  • myocardial fibrosis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis


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