The role of caveolin-enriched microdomains in the regulation of cellular signalling and energy homeostasis

Christopher Lipina, Mitchell H. Whyte, Clare Stretton, Harinder S. Hundal

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Lipid rafts are nanoscale regions of the plasma membrane with distinct structural compositions that function to modulate a diverse array of biological processes. In accordance with this, specialised lipid rafts termed caveolae have been implicated as key signalling platforms for various pathways and processes involved in the modulation of energy homeostasis. This chapter aims to highlight and review experimental evidence which supports a role for lipid rafts/caveolae in coordinating signalling events and processes that are crucial for the maintenance of normal glucose and lipid homeostasis. In particular, the involvement of these membrane microdomains in the regulation of insulin action, proinflammatory signalling, mitochondrial function and lipid metabolism will be discussed, as well as their potential role in the pathogenesis of human metabolic disorders.

    Original languageEnglish
    Title of host publicationLipid Rafts
    Subtitle of host publicationProperties, Controversies and Roles in Signal Transduction
    PublisherNova Science Publishers
    Chapter4
    Pages69-103
    Number of pages35
    ISBN (Electronic)9781629489643
    ISBN (Print)9781629489612
    Publication statusPublished - 1 Jan 2014

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