Lipid rafts are nanoscale regions of the plasma membrane with distinct structural compositions that function to modulate a diverse array of biological processes. In accordance with this, specialised lipid rafts termed caveolae have been implicated as key signalling platforms for various pathways and processes involved in the modulation of energy homeostasis. This chapter aims to highlight and review experimental evidence which supports a role for lipid rafts/caveolae in coordinating signalling events and processes that are crucial for the maintenance of normal glucose and lipid homeostasis. In particular, the involvement of these membrane microdomains in the regulation of insulin action, proinflammatory signalling, mitochondrial function and lipid metabolism will be discussed, as well as their potential role in the pathogenesis of human metabolic disorders.
|Title of host publication||Lipid Rafts|
|Subtitle of host publication||Properties, Controversies and Roles in Signal Transduction|
|Publisher||Nova Science Publishers|
|Number of pages||35|
|Publication status||Published - 1 Jan 2014|