The role of DMPK science in improving pharmaceutical research and development efficiency

Kit-Kay Mak (Lead / Corresponding author), Ola Epemolu, Mallikarjuna Rao Pichika (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

Abstract

The successful regulatory authority approval rate of drug candidates in the drug development pipeline is crucial for determining pharmaceutical research and development (R&D) efficiency. Regulatory authorities include the US Food and Drug Administration (FDA), European Medicines Agency (EMA), and Pharmaceutical and Food Safety Bureau Japan (PFSB), among others. Optimal drug metabolism and pharmacokinetics (DMPK) properties influence the progression of a drug candidate from the preclinical to the clinical phase. In this review, we provide a comprehensive assessment of essential concepts, methods, improvements, and challenges in DMPK science and its significance in drug development. This information provides insights into the association of DMPK science with pharmaceutical R&D efficiency.

Original languageEnglish
Number of pages25
JournalDrug Discovery Today
Early online date10 Nov 2021
DOIs
Publication statusE-pub ahead of print - 10 Nov 2021

Keywords

  • DMPK
  • ADME/T
  • Drug discovery and development
  • Pharmaceutical R&D efficiency
  • PBPK modelling
  • Allometric scaling

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