The role of GABAA receptor biogenesis, structure and function in epilepsy

S. Mizielinska; S. Greenwood; C. N. Connolly

doi:10.1042/BST0340863

The role of GABA_Areceptor biogenesis, structure and function in epilepsy

S. Mizielinska
, S. Greenwood
, C. N. Connolly

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Maintaining the correct balance in neuronal activation is of paramount importance to normal brain function. imbalances due to changes in excitation or inhibition can lead to a variety of disorders ranging from the clinically extreme (e.g. epilepsy) to the more subtle (e.g. anxiety). in the brain, the most common inhibitory synapses are regulated by GABA(A) (gamma-aminobutyric acid type A) receptors, a role commensurate with their importance as therapeutic targets. Remarkably, we still know relatively little about GABAA receptor biogenesis. Receptors are constructed as pentameric ion channels, with alpha and beta subunits being the minimal requirement, and the incorporation of a gamma subunit being necessary for benzodiazepine modulation and synaptic targeting. insights have been provided by the discovery of several specific assembly signals within different GABA(A) receptor subunits. Moreover, a number of recent studies on GABA(A) receptor mutations associated with epilepsy have further enhanced our understanding of GABA(A) receptor biogenesis, structure and function.

Original language	English
Pages (from-to)	863-867
Number of pages	5
Journal	Biochemical Society Transactions
Volume	34
Issue number	5
DOIs	https://doi.org/10.1042/BST0340863
Publication status	Published - 2006
Event	Bioscience 2006: Bioscience for the 21st Century - Scottish Exhibition and Conference Centre, Glasgow, United Kingdom Duration: 23 Jul 2006 → 27 Jul 2006 http://www.bioscience2006.org/

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10.1042/BST0340863

The role of GABA_A receptor biogenesis, structure and function in epilepsy
Mizielinska, S., Greenwood, S. & Connolly, C. N., 2006.
Research output: Contribution to conference › Paper

Bioscience 2006: Bioscience for the 21st Century
Greenwood, S. (Participant)
23 Jul 2006 → 27 Jul 2006
Activity: Participating in or organising an event types › Participation in conference

Cite this

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The role of GABAA receptor biogenesis, structure and function in epilepsy

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